Enrichment-Program-001

概述。试点和可行性项目(P/F)计划是核心中心活动的重要组成部分 这促进和促进了JHU的GI研究。我们P/F计划的最高优先事项是提供资金 对对GI表现出兴趣和重大承诺的年轻研究人员提供支持、指导和培训 研究。此外，我们的P/F计划支持对更成熟的研究人员进行高度创新的研究 他们目前没有在GI领域工作，但有兴趣将他们的专业知识应用到研究中 与消化障碍相关的重要机制问题。与NIDDK指南一致， P/F计划可以为现有的GI调查人员提供支持，以开发新的GI研究领域，尽管我们 由于缺乏有说服力的申请和我们的优先资助，尚未资助这一类别的提案 年轻的调查员。在它存在的头三年里，P/F计划已经资助了11个应用程序；所有 这些信息来自初级调查人员。在第四年，我们选择了两个来自Young的申请作为资助 调查人员和两名来自目前在非GI领域工作的更成熟的调查人员。总之，结束了 4年来，申请的平均成功率(资金/提交)为25%，来自年轻人的申请 调查人员占资助项目的82%，而来自新加入的老牌调查人员的申请 该领域占资助项目的18%。我们的P/F计划具有重要的外延，吸引了申请者和 来自临床和基础科学系的成员。大约一半的获奖者(54%)来自 医学系，另一半(46%)--来自细胞生物学、生理学、儿科、 生物物理学、遗传学和材料科学与工程。在三年的时间里，P/F计划投资了 275,000美元，并从各种来源获得2,410,000美元的新资金，投资回报为8.7倍 (按一年资金，直接成本计算；考虑5年资金，收益为8,800,000美元，直接成本，32 折叠回车)。根据美国国立卫生研究院的指导方针，也将在投资后5年和10年内进行评估。 主要目标。 我们广泛的具体目标与以前一样，并遵循NIH关于P/F计划的指导方针 在Silvio O.Conte消化系统疾病研究核心中心。具体地说，P/F计划将 向三类调查员提供资金支持，第一类最优先： 1)没有现任和以前的NIH资助(R01、U或P资助)作为负责人的年轻和新调查人员 研究人员，对胃肠道相关研究表现出兴趣和巨大希望 2)拥有NIH资金(在获奖时或过去有过此类资金)的调查人员是 建立在其他研究学科中，并拥有转移消化系统疾病的专业知识 JHU Forward的研究，但以前没有参与过GI研究。受资助的项目 将在与消化道相关的实验系统中测试创新工具和概念。 3)已经在研究消化系统疾病的研究人员，他们建议对 他们的研究方向。 P/F奖励将支持旨在生成全尺寸所需的额外初步数据的项目 批准国家卫生研究院(R01机制)以及其他资助机构的申请。来自新的应用程序 并建立研究人员，测试新概念，利用创新的实验系统或提议进行 不同学科交界处的地理信息研究将具有重要的支撑作用。除了金融以外 除了援助，P/F方案还为最近任命的年轻调查人员提供指导和指导 作为展示他们的研究和检验他们的想法的机会。 实现我们目标的具体计划。 申请征集、遴选和审查的主要方法将与目前的做法保持不变 P/F计划，基于我们在该计划中取得的成功。具体来说，确定P/F项目 申请资金将遵循5个步骤(在申请中详细介绍)，包括广告、内部 我们的外部科学咨询委员会(AN)对资格进行审查，对科学功绩进行评估 独立的外部委员会)、最终遴选和对所有人的反馈(成功和不成功) 申请者。我们将进一步简化申请流程，并推出申请前问答环节 (见下文)，使潜在申请者熟悉指导方针和审查程序。我们还将 继续我们的定期评价方案，并鼓励更广泛地传播P/F结果。一个 新开始的P/F计划的特点是由新获奖者对P/F进行简短的介绍性介绍 在学年开始时正在进行的工作和过去获奖者的总结报告结束 每一学年。我们还将加强目前对年轻实习生的指导。我们将继续鼓励 这一群体申请更大的NIH R01类型的拨款；然而，我们P/F计划的一个新功能是 建议申请者将他们的资助金发送到最近成立的JHU进行初步评估和反馈 “专家小组”由资深科学家组成，他们在撰写/审查拨款方面具有丰富的专业知识。

Overview. The Pilot and Feasibility Project (P/F) program is an important component of Core Center activities that facilitates and promotes GI research at JHU. The highest priority of our P/F program is to provide financial support, mentoring, and training to young investigators who have shown interest and significant promise in GI research. In addition, our P/F program supports highly innovative research of more established investigators who are not currently working in the GI field but are interested in applying their expertise to studies that answer important mechanistic questions related to digestive disorders. In agreement with the NIDDK guidelines, the P/F program can offer established GI investigators support to develop new areas of GI research, although we have not yet funded proposals in this category due to lack of compelling applications and our priority of funding young investigators. In the first 3 years of its existence, the P/F program has funded 11 applications; all of those were from junior investigators. In the fourth year, we selected for funding two applications from young investigators and two from more established investigators currently working in non-GI fields. Altogether, over the 4 years, the average success rate (funded/submitted) of applications is 25%, the applications from young investigators represent 82% of funded projects, and the applications from established investigators new to the field constitute 18% of funded projects. Our P/F program has significant outreach, attracting applicants and members from both clinical and basic science departments. About half of our awardees (54%) came from the Department of Medicine, another half (46%) – from the Departments of Cell Biology, Physiology, Pediatrics, Biophysics, Genetics, and Material Science and Engineering. Over three years, the P/F program invested $275,000 and yielded $2,410,000 of new funds from various sources, an 8.7 fold return on investment (calculated on one year funding, direct costs; considering 5 year funding, yield is $8,800,000, direct costs, a 32 fold return). In agreement with NIH guidelines, evaluation will also be done at 5 and 10 years after investment. Main Goals. Our broad Specific Aims remain the same as previously and follow the NIH guidelines for the P/F programs under the Silvio O. Conte Digestive Diseases Research Core Centers. Specifically, the P/F program will provide financial support to three categories of investigators, with highest priority for category 1: 1) Young and new investigators without current and prior NIH support (R01, U, or P grants) as Principal Investigators, who show interest and great promise in GI related research 2) Investigators, who have NIH funding (at the time of the awards or had such funding in the past), are established in other research disciplines, and have expertise that would move digestive disease research at JHU forward but have not previously taken part in GI research. The supported projects would test innovative tools and concepts in the experimental systems relevant to the digestive tract. 3) Investigators already working in digestive diseases, who propose to make a substantial change in the direction of their research. The P/F awards will support projects that aim to generate additional preliminary data necessary for full-size grant applications to the NIH (the R01 mechanism) as well as other funding agencies. Applications from new and establish investigators that test novel concepts, utilize innovative experimental systems or propose to carry the GI research at the interface of different disciplines will have significant support. In addition to financial assistance, the P/F program offers mentoring and guidance to recently appointed young investigators, as well as opportunity to showcase their research and test their ideas. Specific plans to achieve our goals. The main approaches to application solicitation, selection, and review will remain unchanged from our current P/F program, based on the success we have had with this program. Specifically, identification of P/F projects for funding will follow a 5-step process (outlined in detail in the application) including advertising, internal review for eligibility, evaluation of scientific merit by our External Scientific Advisory Committee (an independent external committee), final selection, and feedback to all (successful and non-successful) applicants. We will further streamline the application process and introduce a pre-application Q&A session (see below) to familiarize the potential applicants with the guidelines as well as review process. We will also continue our program of regular evaluations, as well as encouraging wider dissemination of the P/F results. A newly begun feature of the P/F program involves a brief introductory presentation of the P/F by new awardees at Work-in-Progress at the beginning of the academic year and summary reports by past awardees ending each academic year. We will also enhance current mentoring of young trainees. We will continue to encourage applications from this group for larger NIH R01-type grants; however, a new feature of our P/F program is to advise the applicants to send their grants for initial evaluation and feedback to a recently established JHU “Experts panel” composed of senior scientists with significant expertise in grant writing/reviewing.