Center for Cancer Biology

项目总结 Cobre的主要目标是建立在基础科学和转化性癌症的临界质量基础上 在癌症生物学研究中心第一阶段资助期间开发的研究人员。第二阶段 将专注于与人类患者有直接翻译相关性的癌症研究。因此，我们五个项目中的四个 领导者是内科科学家，他们拥有跨越基础、翻译和临床癌症研究的专业知识。会的 目标是将我们的实验室发现转化为人类临床试验。将重点放在Head和 颈部鳞状细胞癌及其免疫系统在治疗中的重要性 疾病。Cobre的持续资助将使我们能够在这一领域建立一支成熟的研究人员核心 谁将在外部同行评审计划项目赠款支持方面具有竞争力，帮助我们 超越科布雷资金的可持续性。儿童癌症的第二个主题将在这段时间内开发出来。 第二阶段的资金。对研究核心设施的持续支持将帮助我们的研究人员获得关键的 提交竞争性赠款申请的初步数据。我们将对学生进行多层次的培训 帮助建设区域癌症研究工作队伍。我们希望博士生和临床科学家在我们的 实验室为癌症研究人员建立成功的职业生涯。为了实现这些目标，我们有 确定了以下几个具体目标：1)支持5个项目负责人的研究，使他们能够 建立有竞争力的、有资金的研究项目。支持将包括指导、参与的机会 培训学生，获得实验室管理、补助金撰写和审查以及出版方面的进一步技能。2)至 建立有效的咨询委员会，指导中心的进一步发展。这将包括内部 咨询委员会和外部咨询委员会。每个委员会都将由备受推崇的 以及拥有与该中心目标相关的专业知识的资深调查人员。3)支持双核 将为项目负责人和其他调查人员提供基本服务的实验室。这个 2个核心实验室将是分子病理学(核心B)和流式细胞术(核心C)。两个内核都是 由第一阶段资金启动，并将由所有第二阶段项目负责人大量使用。4)提供试点项目 提供资金，目的是支持与总主题有关的项目，这些项目有可能导致进一步 外部资金，从而提升整体中心。总体而言，我们希望在这些领域站稳脚跟。 头颈部癌症和儿童癌症，因此在方案项目类型的资助方面具有竞争力(例如： 这将给我们的中心带来长期的稳定。在这一追求中，我们希望进一步发展我们的专业知识 这使得基本发现可以转化为对人类癌症患者的临床试验。

PROJECT SUMMARY The primary goal of the COBRE is to build upon the critical mass of basic science and translational cancer researchers that has been developed during Phase I funding of the Cancer Biology Research Center. Phase II will focus on cancer research with direct translational relevance to human patients. Thus four of our five project leaders are physician scientists with expertise spanning basic, translational, and clinical cancer research. It will be a goal to translate our laboratory findings into human clinical trials. There will be an emphasis on head and neck squamous cell carcinoma and the importance of the immune system in treatment of patients with this disease. Continued COBRE funding will allow us to establish a core of established researchers in this area who will be competitive for external peer-reviewed program project grant support, helping us to reach sustainability beyond COBRE funding. A second theme of childhood cancers will be developed over the period of Phase II funding. Continued support of research core facilities will aid our investigators in obtaining critical preliminary data for the submission of competitive grant applications. We will train students at multiple levels to help build the regional cancer research work force. We expect PhD and clinician scientists who train in our laboratories to establish successful careers as cancer researchers. To accomplish these goals we have established several specific aims as follows: 1) to support the research of 5 Project Leaders allowing them to establish competitive, funded research programs. Support will include mentoring, opportunities to participate in training of students, gaining further skills in lab management, grant writing and reviewing, and publishing. 2) to establish effective advisory committees to guide further development of the center. This will include an Internal Advisory Committee and an External Advisory Committee. Each committee will be made up of highly regarded and established investigators with expertise relevant to the goals of the center. 3) to support two Core Laboratories that will provide essential services in support of the Project Leaders and other investigators. The 2 Core Laboratories will be Molecular Pathology (Core B) and Flow Cytometry (Core C). Both cores were initiated with Phase I funding and will be heavily used by all Phase II project leaders. 4) Provide pilot project funding with the goal of supporting projects related to the overall theme that have the potential to lead to further external funding, thus enhancing the overall center. Overall, we expect to become well established in the areas of head and neck cancer and childhood cancers, thus being competitive for program project type funding (e.g. P01) that will bring long term stability to our center. In this pursuit, we expect to further develop our expertise that allows basic discoveries to be translated into clinical trials in human cancer patients.