人类宫颈粘液塞在 GBS 上行感染中的作用-猫眼课题宝

人类宫颈粘液塞在 GBS 上行感染中的作用

批准号：

9303886

负责人：

Lakshmi Rajagopal

金额：

$23.37万

依托单位：

SEATTLE CHILDREN'S HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

已结题

起止时间：

2016-06-24 至 2020-05-31

来源：

https://reporter.nih.gov/project-details/9303886

关键词：

Accounting Acids Adult Amniotic Fluid Anabolism Anti-Bacterial Agents Bacteria Bacterial Genes Bacterial Infections Cervical Cervix Mucus Cystatins Data Defensins Development Event Fetus Gene Expression Gene Proteins Genes Genetic Transcription Global Change Goals Gram-Positive Bacteria Growth Growth Factor Human Infection Injury Integration Host Factors Lactoferrin Leukocyte L1 Antigen Complex Microbe Morbidity - disease rate Mucous body substance Muramidase Nature Neonatal Neonatal Mortality Newborn Infant Organism Peptide Hydrolases Peptides Permeability Plug-in Predisposition Pregnancy Pregnant Women Premature Birth Premature Labor Prevention Property Protein Secretion Proteins Public Health Recovery Reporting Role Serotyping Signal Transduction Streptococcal Infections Streptococcus Group B Supplementation Symbiosis Therapeutic Toxic effect Ureaplasma Uterus Vagina Virulence Factors Woman amniotic cavity antileukoprotease antimicrobial antimicrobial drug antimicrobial peptide capsule clinically significant early onset effective therapy fetal human mortality in utero insight intraamniotic infection microbial microorganism neonatal morbidity novel pathogen placental membrane prevent reproductive tract resistance mechanism risk minimization stillbirth transmission process

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中文摘要

翻译

项目总结导致人类新生儿发病和死亡的细菌感染仍然是重要的公共卫生问题担忧。B组链球菌(GBS)是一种革兰氏阳性细菌，可导致早产、死产和人类新生儿的早发性感染。尽管GBS通常以共生生物的形式存在于健康女性的下生殖道(LGT)，促进GBS从LGT传播到怀孕期间的羊膜腔和胎儿情况尚不清楚。这项建议的目标是界定人宫颈粘液塞在预防GBS生长中的作用及确定GBS是否感觉到CMPs 并修饰毒力因子表达，导致上行感染和胎儿损伤。

英文摘要

PROJECT SUMMARY Bacterial infections leading to morbidity and mortality of human newborns remain significant public health concerns. Group B Streptococci (GBS) are Gram-positive bacteria that cause preterm births, stillbirths and early onset infections in human newborns. Although GBS normally reside as commensal organisms in the lower genital tract (LGT) of healthy women, the events that promote transmission of GBS from the LGT to the amniotic cavity and fetus during pregnancy are unknown. The objective of this proposal is to define the role of the human cervical mucus plug in prevention of GBS growth and to determine if GBS sense CMP and modify virulence factor expression leading to ascending infection and fetal injury.

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