UAB Nutrition Obesity Research Center (NORC)

我们要求重新提供资金，以继续和扩大UAB‘s Nutrition取得的有据可查的成功 肥胖研究中心(NORC)在其前三个资金周期。2000年，在NIH的资助下成立了我们的 NORC促进多学科、协作性、基础性、临床和转化性的营养和肥胖研究。 自最初获得资金以来，NORC的研究基础已经大幅增长。在2000年成立时，我们有 60名成员。到我们2011年最后一次续签时，这一数字已增加到134个； 今天有178名成员。在2000年，我们的成员以PI的身份举办了15个R01或K-奖项，显然与 营养或肥胖。截至2016年撰写本文时，我们的成员以PI的身份持有48个R01、R00和K-奖，这些奖项是 显然与营养或肥胖有关。在过去的资金周期中，UAB的NORC直接帮助招募了超过 15名新的和现有的肥胖和营养研究人员。我们的出版物产量在#年稳步增长 绝对数字和世界上关于肥胖和营养的文献的比例。NORC的影响 根据NIH的相对引文率判断的出版物一直超过同行评议文献的标准 在肥胖和营养方面，特别是在NIH资助的研究中，这一比例超过了50%。我们的 NORC领导层监督NIH资助的两项肥胖研究T32培训拨款，还有两项培训 赠款正在审查中，目标是在下一个供资周期提交第三份赠款。过去新发起的资金 周期，我们的NORC领导了一系列由美国国立卫生研究院资助的营养和肥胖相关的年度短期课程 由三个新的R25赠款支持。我们的NORC每年至少资助四项试点和可行性研究， 赞助一名指定的新调查员，并实施一项广泛的丰富计划。UAB为我们提供了 NORC每年超过75万美元，以增加NIDDK P30赠款。NORC的新陈代谢，动物模型， 体力活动和生物统计核心蓬勃发展，导致具有成本效益的研究和增强 获得被我们的成员大量使用的尖端技术。我们的主要主题是肥胖： 原因、后果和缓解。在接下来的周期中，这个大范围内的重要子域 主题将被强调。这些子领域包括(1)少数族裔之间的肥胖和健康差距；(2) 残疾人中的肥胖、饮食、减肥和运动；(3)肥胖、能量消耗和老龄化；(4) 跨代、发育和儿科方面；和(5)数学/定量科学 接近了。在特殊的机构支持和学术基础设施的支持下，我们要求更新 为继续我们对这一重要研究领域的贡献提供资金。

We request renewed funding to continue and expand on the documented success achieved by UAB's Nutrition Obesity Research Center (NORC) in its first three funding cycles. Inaugurated with NIH funding in 2000, our NORC fosters multidisciplinary, collaborative, basic, clinical, and translational nutrition and obesity research. Since it was first funded, the NORC's research base has grown substantially. At its inception in 2000, we had 60 members. By the time of our last renewal in 2011 this number had increased to 134 members; the number today stands at 178 members. In 2000, our members held as PIs 15 R01s or K-awards clearly related to nutrition or obesity. As of this writing in 2016, our members hold as PIs 48 R01s, R00s and K-awards that are clearly related to nutrition or obesity. In the past funding cycle, UAB's NORC has directly helped to recruit over 15 new and established obesity and nutrition investigators. Our publication output has steadily increased in absolute numbers and as a proportion of the world's literature on obesity and nutrition. The impact of NORC publications as judged by NIH’s relative citation ratio consistently exceeds the norm for peer-reviewed literature on obesity and nutrition in general and even for NIH-funded research in particular by a factor of over 50%. Our NORC leadership oversees two NIH-funded T32 training grants for obesity research, has two more training grants in review, and aims to submit a third in the coming funding cycle. Newly initiated in the past funding cycle, our NORC has led a series of national NIH-funded nutrition and obesity-related annual short courses supported by three new R25 grants. Our NORC funds at least four Pilot & Feasibility studies per year, sponsors a Named New Investigator, and implements an extensive Enrichment Program. UAB provides our NORC over $750,000 annually to enhance the NIDDK P30 grant. The NORC’s Metabolism, Animal Models, Physical Activity, and Biostatistics Cores have flourished, resulting in cost-effective research and enhanced access to cutting-edge technology that is heavily utilized by our members. Our primary theme is Obesity: Causes, Consequences, and Alleviation. During the coming cycle, important subdomains within this broad theme will be emphasized. These subdomains include (1) obesity and health disparities among minorities; (2) obesity, diet, weight loss, and exercise among persons with disabilities; (3) obesity, energetics, and aging; (4) transgenerational, developmental, and pediatric aspects; and (5) mathematical/quantitative science approaches. Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our contributions to this important area of research.