Informatics Center for Neurogenetics and Neurogenomics - Analysis Core

项目摘要 此申请是为了更新NINDS P30机构中心核心，NINDS信息中心， 神经遗传学和神经基因组学。ICNN成立于2009年，旨在促进遗传学研究， 为加州大学洛杉矶分校的大型和高度互动的神经科学社区的成员提供基因组学。过去 在资助周期内，ICNN 1）加快了来自8名NINDS资助研究人员的10个项目的进展 在初始申请中指定; 2）通过ARRA补充和销售和服务协议， 扩大了它的范围，并支持了加州大学洛杉矶分校的其他神经科学家，所以它现在参与了三分之一的研究。 在所有授予加州大学洛杉矶分校神经科学家的NINDS R 01中， 研究; 3）为29篇出版物（提交了8篇）做出了贡献，并成功申请了多项赠款，包括 培训奖励指导;以及4）扩大其教师和分析组合，以强调合作 在计算生物学和神经遗传学的领导者之间， 用于数据分析。总之，ICNN在其最初的获奖期间，为长期的，自我的， 一个持续的实体支持基因组神经科学研究在加州大学洛杉矶分校，并促进了一些项目 和培训赠款。随着教师队伍的扩大和坚实的计算基础设施的到位， 上一个资助周期，ICNN在更新中建议继续支持NINDS赠款（9个命名中的15个） 用户），继续开发创新的遗传学和基因组学方法，并继续促进 神经遗传学和神经基因组学。

PROJECT SUMMARY This application is to renew an NINDS P30 Institutional Center Core, the NINDS Informatics Center for Neurogenetics and Neurogenomics, ICNN. The ICNN, founded in 2009, facilitates research in genetics and genomics for members of the large and highly interactive neuroscience community at UCLA. Over the past funding cycle, ICNN has 1) accelerated the progress of ten projects from eight NINDS-funded investigators specified in the initial application; 2) through an ARRA supplement and a sales and service agreement, extended its scope and support to additional neuroscientists at UCLA, so that is it is now involved in one third of all the NINDS R01s awarded to UCLA neuroscientists, essentially all the ones encompassing genomic studies; 3) contributed to 29 publications (+8 submitted), and multiple successful grant applications, including mentoring on training awards; and 4) expanded its faculty and analysis portfolio, to emphasize collaborations between leaders in computational biology and neurogenetics, and the implementation of innovative methods for data analysis. In summary, ICNN, in its initial award period, laid the foundation for a long-term, self- sustained entity supporting genomics neuroscience research at UCLA and has facilitated a number of projects and training grants. With an expanded faculty and a solid computational infrastructure put in place in the previous funding cycle, ICNN proposes in the renewal to continue to support NINDS grants (15 from 9 named users), to continue to develop innovative genetics and genomics approaches, and to continue to foster neurogenetics and neurogenomics for the neuroscience community at UCLA.