CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGY RESEARCH

 描述（由申请人提供）：此T32应用程序旨在为儿科风湿病研究员提供必要的调查技能，以便在学术儿科风湿病方面取得有意义的科学事业。该计划是基于一个大型的儿科流变学（PR）部门，有几个中心赠款（P30，P01）和NIH资助的研究人员。儿科流变学分部，包括其相关诊所，是辛辛那提儿童医院医学中心（CCHMC）和儿童医院研究基金会（TCHRF）的一部分，也是辛辛那提大学医学院（UCCOM）及其临床和生物医学科学系的一部分。儿科流变学部门的研究计划从独特的临床，翻译和基础研究人员的综合团队中汲取力量，这些研究人员参与了与免疫生物学，人类遗传学，血液学/肿瘤学，骨髓移植，肾脏学，药理学，放射学，心理学和生物信息学部门成员的积极持续合作。主要的教师顾问是从15个专业部门的基础上与流变学教师的持续合作，高研究生产力和年轻科学家培训的良好记录选择。虽然主要重点将放在医学博士和医学博士/博士学员在公关奖学金计划，博士候选人在儿科风湿性疾病的转化研究具有浓厚的兴趣，以及将寻求。大多数学员将把他们的研究和培训活动集中在两个特别强调的优势领域之一，这是CCHMC研究中心和流变学部门所独有的：（1）应用生物信息学和“组学”技术，包括基因组学、表观遗传学、蛋白质组学和代谢组学，以推进与儿科风湿病相关的转化研究，和（2）临床流行病学，临床结果评估工具的开发和临床试验设计。该计划得到了核心设施和学术课程的大力支持，包括医学伦理学的必修课程。其他课程包括计算系统生物学、免疫生物学、分子遗传学、流行病学和生物统计学。跨部门的免疫生物学研究生课程（MS和PhD）以CCHMC为中心，补充了UCCOM的流行病学和生物统计学以及教育方面的现有课程。据信，这一培训计划为小儿风湿病研究提供了独特的资源，并将继续扩大个人与生物医学科学的职业兴趣，因为它涉及到小儿风湿病，这是一个池太小，以满足未来几十年的要求，分子医学越来越多地应用于临床。

 DESCRIPTION (provided by applicant): This T32 application seeks to equip pediatric rheumatology fellows with the investigative skills necessary to succeed in meaningful scientific careers in academic pediatric rheumatology. The program is based in a large Division of Pediatric Rheumatology (PR) with several center grants (P30, P01) and NIH-funded investigators. The Pediatric Rheumatology Division, including its related clinic, is part of Cincinnati Children's Hospital Medical Center (CCHMC) and The Children's Hospital Research Foundation (TCHRF), as well as part of the University of Cincinnati College of Medicine (UCCOM) with its clinical and biomedical science departments. The Pediatric Rheumatology divisional research program draws strength from uniquely integrated teams of clinical, translational and basic researchers involved in active ongoing collaborations with members of Divisions of Immunobiology, Human Genetics, Hematology/Oncology, Bone Marrow Transplantation, Nephrology, Pharmacology, Radiology, Psychology and Bioinformatics. The primary faculty advisors were selected from 15 specialties divisions based on the ongoing collaboration with Rheumatology faculty, high research productivity and strong record of training of young scientists. Although the main emphasis will be placed on MD and MD/PhD trainees in the PR Fellowship Program, PhD candidates with strong interest in translational research in pediatric rheumatologic diseases will be sought as well. The majority of trainees will focus their research and training activities in one of the two special emphasis areas of strength, unique to the CCHMC research center and the Division of Rheumatology: (1) application of bioinformatics and "omics" technologies including genomics, epigenetics, proteomics, and metabolomics to advance translational research related to pediatric rheumatology, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. The program is well supported by core facilities as well as by academic courses, including a mandatory course in medical ethics. Other available courses include computational system biology, immunobiology, molecular genetics, and epidemiology and biostatistics. The interdepartmental Immunobiology Graduate Program (MS and PhD) that is centered at CCHMC complements existing programs in Epidemiology and Biostatistics, and Education in the UCCOM. It is believed that this Training Program for Pediatric Rheumatic Disease Research provides unique resources and will continue to enlarge the pool of individuals with a career interest in biomedical science as it relates to pediatric rheumatology, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.