CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGYRESEARCH

辛辛那提儿科风湿病学研究培训计划

• 批准号: 10682443
• 负责人: ALEXEI A GROM
• 金额: $ 14.17万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682443
• 关键词: Childhood; Training Programs

PROJECT SUMMARY/ABSTRACT This T32 application seeks to equip pediatric rheumatology fellows with the investigative skills necessary to succeed in meaningful scientific careers in academic pediatric rheumatology. The program is based in a large Division of Pediatric Rheumatology (PR) with several center grants and NIH-funded investigators. The Pediatric Rheumatology Division, including its related clinic, is part of Cincinnati Children's Hospital Medical Center (CCHMC) and The Children's Hospital Research Foundation (TCHRF), as well as part of the University of Cincinnati College of Medicine (UCCOM) with its clinical and biomedical science departments. The Pediatric Rheumatology divisional research program draws strength from uniquely integrated teams of clinical, translational and basic researchers involved in active ongoing collaborations with members of Divisions of Immunobiology, Human Genetics, Hematology/Oncology, Bone Marrow Transplantation, Nephrology, Pharmacology, Radiology, Psychology and Bioinformatics. The primary faculty advisors were selected from 15 specialties divisions based on the ongoing collaboration with Rheumatology faculty, high research productivity and strong record of training of young scientists. Although the main emphasis will be placed on MD and MD/PhD trainees in the PR Fellowship Program, PhD candidates with strong interest in translational research in pediatric rheumatologic diseases will be sought as well. The majority of trainees will focus their research and training activities in one of the two special emphasis areas of strength, unique to the CCHMC research center and the Division of Rheumatology: (1) application of bioinformatics and “omics” technologies including genomics, epigenetics, proteomics, and metabolomics to advance translational research related to pediatric rheumatology, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. The program is well supported by core facilities as well as by academic courses, including a mandatory course in medical ethics. Other available courses include computational system biology, immunobiology, molecular genetics, and epidemiology and biostatistics. The interdepartmental Immunobiology Graduate Program (MS and PhD) that is centered at CCHMC complements existing programs in Epidemiology and Biostatistics, and Education in the UCCOM. It is believed that this Training Program for Pediatric Rheumatic Disease Research provides unique resources and will continue to enlarge the pool of individuals with a career interest in biomedical science as it relates to pediatric rheumatology, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.

项目总结/摘要 这个T32应用程序旨在为儿科风湿病学研究员提供调查技能 在学术儿科风湿病学有意义的科学事业中取得成功是必要的。的 该计划是基于一个大型部门的儿科流变学（公关）与几个中心赠款 和NIH资助的研究人员儿科流变学分部，包括其相关诊所， 隶属于辛辛那提儿童医院医疗中心（CCHMC）和儿童医院 研究基金会（TCHRF），以及部分辛辛那提大学学院 医学（UCCOM）及其临床和生物医学科学部门。儿科 流变学部门研究计划从独特的综合团队中汲取力量， 临床，翻译和基础研究人员参与积极进行合作， 免疫生物学、人类遗传学、血液学/肿瘤学、骨 骨髓移植、肾脏病学、药理学、放射学、心理学和 生物信息学。主要的教师顾问是从15个专业部门的基础上选择的 与流变学教师的持续合作，高研究生产力和强大的 培养青年科学家。虽然主要重点将放在MD和 PR奖学金计划中的MD/PhD学员，对以下方面有浓厚兴趣的博士候选人 也将寻求儿科风湿病的转化研究。大多数 受训人员的研究和培训活动将侧重于两个特别重点领域之一 CCHMC研究中心和流变学部独有的实力：（1） 生物信息学和“组学”技术的应用，包括基因组学，表观遗传学， 蛋白质组学和代谢组学，以推进与儿科相关的转化研究 风湿病学，和（2）临床流行病学，临床结果评估工具的开发 和临床试验设计。该计划得到了核心设施和学术机构的大力支持。 课程，包括医学伦理学必修课。其他可用的课程包括 计算系统生物学、免疫生物学、分子遗传学和流行病学， 生物统计学跨部门的免疫生物学研究生课程（MS和PhD）， 以CCHMC为中心，补充了流行病学和生物统计学的现有课程， 在UCCOM的教育。据认为，这一培训计划，小儿风湿性关节炎， 疾病研究提供了独特的资源，并将继续扩大个人库 与生物医学科学的职业兴趣，因为它涉及到儿科风湿病，一个池， 太小，无法满足未来几十年的要求，因为分子医学是 越来越多地应用于临床。