CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGYRESEARCH

辛辛那提儿科风湿病学研究培训计划

• 批准号: 10266008
• 负责人: ALEXEI A GROM
• 金额: $ 13.46万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10266008
• 关键词: Childhood; Training Programs

PROJECT SUMMARY/ABSTRACT This T32 application seeks to equip pediatric rheumatology fellows with the investigative skills necessary to succeed in meaningful scientific careers in academic pediatric rheumatology. The program is based in a large Division of Pediatric Rheumatology (PR) with several center grants and NIH-funded investigators. The Pediatric Rheumatology Division, including its related clinic, is part of Cincinnati Children's Hospital Medical Center (CCHMC) and The Children's Hospital Research Foundation (TCHRF), as well as part of the University of Cincinnati College of Medicine (UCCOM) with its clinical and biomedical science departments. The Pediatric Rheumatology divisional research program draws strength from uniquely integrated teams of clinical, translational and basic researchers involved in active ongoing collaborations with members of Divisions of Immunobiology, Human Genetics, Hematology/Oncology, Bone Marrow Transplantation, Nephrology, Pharmacology, Radiology, Psychology and Bioinformatics. The primary faculty advisors were selected from 15 specialties divisions based on the ongoing collaboration with Rheumatology faculty, high research productivity and strong record of training of young scientists. Although the main emphasis will be placed on MD and MD/PhD trainees in the PR Fellowship Program, PhD candidates with strong interest in translational research in pediatric rheumatologic diseases will be sought as well. The majority of trainees will focus their research and training activities in one of the two special emphasis areas of strength, unique to the CCHMC research center and the Division of Rheumatology: (1) application of bioinformatics and “omics” technologies including genomics, epigenetics, proteomics, and metabolomics to advance translational research related to pediatric rheumatology, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. The program is well supported by core facilities as well as by academic courses, including a mandatory course in medical ethics. Other available courses include computational system biology, immunobiology, molecular genetics, and epidemiology and biostatistics. The interdepartmental Immunobiology Graduate Program (MS and PhD) that is centered at CCHMC complements existing programs in Epidemiology and Biostatistics, and Education in the UCCOM. It is believed that this Training Program for Pediatric Rheumatic Disease Research provides unique resources and will continue to enlarge the pool of individuals with a career interest in biomedical science as it relates to pediatric rheumatology, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.

项目摘要/摘要 此T32应用程序旨在使儿科风湿病研究员具备调查技能 在儿科风湿病学学术领域取得有意义的科学成就所必需的。这个 该计划的总部设在儿科风湿病(PR)的一个大部门，并有几个中心赠款 以及美国国立卫生研究院资助的调查人员。儿科风湿科，包括其相关的诊所， 隶属于辛辛那提儿童医院医疗中心(CCHMC)和儿童医院 研究基金会(TCHRF)，以及辛辛那提大学 医学(UCCOM)及其临床和生物医学科学部。儿科 风湿病分部研究计划从独特的整合团队中汲取力量 参与积极的持续合作的临床、翻译和基础研究人员 免疫生物学、人类遗传学、血液学/肿瘤学、骨科 骨髓移植、肾脏病、药理学、放射学、心理学和 生物信息学。初级教师顾问是从15个专业科室中挑选出来的。 与风湿病学院的持续合作，高研究效率和强大的 青年科学家培养实录。虽然主要的重点将放在MD和 公关奖学金计划的博士/博士实习生，对以下领域有浓厚兴趣的博士生 儿童风湿病的翻译研究也将被寻求。大多数人 受训者将把他们的研究和培训活动集中在两个特别强调领域之一 CCHMC研究中心和风湿病学部独有的实力：(1) 生物信息学和包括基因组学、表观遗传学、 蛋白质组学和代谢组学促进与儿科相关的翻译研究 风湿学，以及(2)临床流行病学，临床结果评估工具的开发 和临床试验设计。该计划得到了核心设施和学术机构的良好支持 课程，包括一门医学伦理学必修课。其他可用的课程包括 计算系统生物学、免疫生物学、分子遗传学和流行病学 生物统计学。跨部门免疫生物学研究生项目(硕士和博士)，即 以CCHMC为中心补充了现有的流行病学和生物统计学项目，以及 加州大学洛杉矶分校的教育。相信这项针对儿童风湿病的培训计划 疾病研究提供了独特的资源，并将继续扩大个人池 在与儿科风湿病相关的生物医学科学方面有职业兴趣，这是一个 太小了，不能像分子医学那样满足未来几十年的要求 越来越多地应用于临床。