Lipid antigen recognition by diverse CD1-restricted T cells

自然杀伤T（NKT）细胞是一种特化的T细胞谱系，其形成针对感染、过敏、癌症和自身免疫性疾病的保护所需的适应性免疫应答的关键部分。存在不同类型的NKT细胞，其表达不同的T细胞受体，所述T细胞受体识别在疾病状况期间呈现的大量脂质抗原。了解脂质识别所涉及的机制对于解释如何操纵NKT细胞以实现所需的免疫应答至关重要。

Natural Killer T (NKT) cells are a specialized T cell lineage that form a key part of the adaptive immune response required for protection against infection, allergy, cancer and autoimmune diseases. Different types of NKT cells exist, expressing distinct T cell receptors that recognize a large array of lipid antigens presented during disease conditions. Understanding the mechanisms involved in lipid recognition is crucial in deciphering how NKT cells can be manipulated for desired immune responses.