University of Pittsburgh Clinical and Translational Science Institute

2006年，我们创建了匹兹堡大学临床和翻译科学研究所(CTSI)，作为 宾夕法尼亚州西部临床和转化科学的学术之家。我们彻底改变了 在皮特大学和我们的合作机构匹兹堡大学医学中心进行的翻译研究 (UPMC)，通过培训850名翻译科学家，将团队科学纳入晋升和终身教职 流程，支持2225名调查人员和4049项研究，并打造合作研究 环境。我们创建并领导了SPIRIT联盟(6个CTSA中心)和NCATS临床应计项目 试验网络(21个CTSA枢纽)。从广泛的翻译研究中出版的手稿 那些直接受益于CTSI支持的项目在文献中被引用了81,000次。在接下来的5年里 年内，我们将应用我们的基础设施、培训计划、最佳做法和新方法来支持 翻译科学和科学家，并通过我们的总体目标推进国家CTSA的每一个目标： 1)劳动力发展：加强和扩大我们多样化和以团队为导向的翻译科学 通过为员工提供晋升所需的专业技能、知识和核心能力 通过创新的教育方法、体验式培训和持续培训来转化他们的发现 学习机会；2)协作和参与：让一个包容各方的利益攸关方小组参与进来 合作伙伴参与完整的翻译研究过程，并使他们作为团队成员做出贡献 开展协作研究；3)整合：将符合以下条件的人群纳入研究计划 传统上被排除在外或孤立地研究，并支持和加强跨越寿命的研究 和翻译研究领域；4)方法/流程：促进创新、质量和效率 通过开发和传播新的研究方法来进行翻译研究；采用 来自CTSA中心、行业和翻译科学以外的部门的最佳实践；促进项目 管理；以及精简机构研究流程，重点是多中心临床 试验；和5)信息学：在研究生命周期中注入信息学工具和方法 翻译研究谱，高效地将研究和临床数据集成到安全的研究数据中 存储库，并实现本地和全国范围内的安全数据共享。除了7个必需的组件和 我们严格的KL2和TL1培训计划，我们将扩大我们的成就范围和广度 通过两个可选组件利用创新作为 学科与生物医学建模。因此，CTSI的影响及其特殊的机构支持和 忠诚和热情的团队，将继续在当地、地区和国家发挥重要作用。

In 2006, we created the University of Pittsburgh Clinical and Translational Science Institute (CTSI) as the academic home for clinical and translational science in western Pennsylvania. We revolutionized the practice of translational research at Pitt and at our partnering institution, the University of Pittsburgh Medical Center (UPMC), by training 850 translational scientists, incorporating team science in the promotions and tenure process, supporting 2225 investigators and 4049 research studies, and forging a collaborative research environment. We created and led the SPIRiT Consortium (6 CTSA hubs) and the NCATS Accrual to Clinical Trials network (21 CTSA hubs). Published manuscripts from a broad range of translational research studies that directly benefitted from CTSI support have been cited >81,000 times in the literature. Over the next 5 years, we will apply our infrastructure, training programs, best practices, and novel approaches to support translational science and scientists and to advance each of the national CTSA goals through our Overall Aims: 1) Workforce Development: Enhance and expand our diverse and team-oriented translational science workforce by providing them with the specialized skills, knowledge, and core competencies required to advance translation of their discoveries through innovative education methods, experiential training, and continuous learning opportunities; 2) Collaboration and Engagement: Engage an inclusive group of stakeholders as partners in the full translational research process and enable their contributions as members of teams conducting collaborative research; 3) Integration: Integrate into research programs those populations that have been traditionally excluded or studied in isolation and support and enhance studies that span the lifespan and translational research spectrum; 4) Methods/Processes: Promote innovation, quality, and efficiency across the translational research spectrum by developing and disseminating new research methodologies; adopting best practices from CTSA hubs, industry, and sectors outside of translational science; facilitating project management; and streamlining institutional research processes, with an emphasis on multi-center clinical trials; and 5) Informatics: Infuse informatics tools and methodologies across the research life cycle and translational research spectrum, efficiently integrate research and clinical data in a secure research data repository, and enable secure data sharing locally and nationally. In addition to the 7 required Components and our rigorous KL2 and TL1 training programs, we will expand our range and breadth of accomplishments through two Optional Components that leverage great strengths and opportunities in Innovation as a Discipline and Biomedical Modeling. Thus, the impact of CTSI, with its exceptional institutional support and committed and enthusiastic team, will continue to be significant, locally, regionally, and nationally.