IGF::OT::IGF: SBIR PHASE II, TOPIC 331: OPTICAL BIOSENSOR FOR REAL-TIME ASSESSMENT OF TUMOR CELLULARITY DURING CORE NEEDLE BIOPSY PROCEDURES.

该项目的长期目标是开发一种新技术，并将其转化为临床应用，以帮助介入放射科医生提高核心针活检手术的成功率。虽然超声或CT被用来确定肿瘤的位置，从而指导活检针的插入，但这些技术不能提供确定肿瘤细胞的必要分辨率。众所周知，许多肿瘤是异质性的（活的肿瘤、坏死、纤维化和炎症的混合物），因此，由于无法收集足够或足够的材料进行组织学分析，介入放射科医生在进行活检时遇到了严峻的挑战。因此，活检成功率在很大范围内变化，从65%到95%，取决于医生的技能，肿瘤大小和活检位置。

The long term goal of this program is to develop and translate to clinical use a novel technology that will help interventional radiologists to improve the success rate of the core needle biopsy procedures. Although ultrasound or CT are used to identify tumor location and thus to guide biopsy needle insertion, these technologies do not provide the necessary resolution to determine tumor cellularity. It is known that many tumors are heterogeneous (mixture of viable tumor, necrosis, fibrosis and inflammation), and therefore interventional radiologists encounter serious challenges when performing biopsies due to the inability of collecting sufficient or adequate material for histological analysis. As a result, biopsy success varies within a large range, from 65 to 95%, depending on the physician skills, tumor size, and biopsy location.