Alcohol Intervention Treatment Outcome Research Training

 描述(由申请者提供)：我们项目的目标是培养博士后生物医学、行为、卫生保健和其他公共卫生科学家，以进行酒精滥用和酒精中毒的治疗和早期干预的研究。一个首要目标是提高推进酒精滥用治疗研究所需的科学推理技能。从我们的角度来看，这类研究将受益于由复杂和充分发展的理论指导的干预措施，该理论使用多学科框架，其中包括干预发生的生物、心理、社会和文化背景。虽然其他机构培训计划可能涉及治疗/早期干预研究，但这是该计划的主要任务。我们培训计划的显著特点是：它是跨学科的；它不包含与酒精或药物滥用有关的功能障碍的性质的单一意识形态或理论；它提供连续的早期干预和治疗培训；它为受训者提供高度个性化的机会，以发展竞争性赠款 通过这样做，为酒精相关功能障碍和治疗的基础贡献新的知识。培训经验的结构是为了提供个性化的研究经验和培训，并辅之以共同的学术课程，研究员将20%的培训时间分配给该课程。课程包括四个不同的领域：(1)统计/研究方法；(2)赠款；(3)研究中的伦理问题；(4)为期两年的正规课程，从不同的学科角度涵盖危险饮酒和酒精使用障碍的病因学和治疗。我们还订阅了在研究导师的指导下的研究学徒模式。研究员的个人研究培训经验来自研究员制定的个性化发展计划(IDP)，并得到他/她的导师的同意，并经培训委员会审查和批准。该计划主要强调创新治疗开发和临床试验方面的培训，其次强调将临床疗效研究转化为服务、有效性和成本效益研究。我们在神经生物学和神经成像、行为遗传学和酒精管理方面的教学和研究经验将我们的翻译研究重点从基础研究扩展到临床研究。预计培训计划期限为两年，但有时我们会将培训期限延长至三年。我们为在研究方法方面接受较少广泛培训的研究员；交叉培训的研究员，例如将艾滋病毒/艾滋病培训添加到酒精研究的主要背景中；或者为每个队列中需要更多时间来实现成为独立调查人员的目标的研究员提供3年。该项目平均每年接收3至4名新研究员。在任何给定的时间，都可能有9到10名研究员常驻。然而，为了遵守50万美元的预算上限，我们目前要求为总共8名研究员提供资金。这与本培训计划之前的10个部分相比有所减少。

 DESCRIPTION (provided by applicant): The aim of our program is to train post-doctoral biomedical, behavioral, health care and other public health scientists to conduct research on treatment and early interventions for alcohol abuse and alcoholism. An overarching goal is to enhance the scientific reasoning skills needed to advance treatment research in alcohol abuse. From our perspective such research will benefit from interventions guided by sophisticated and fully developed theory using a multidisciplinary framework that includes the biological, psychological, social and cultural context in which interventions occur. While other institutional training programs may address treatment/early intervention research, this is the primary mission for this program. Distinctive features of our training program are: that it is interdisciplinary; tat it embraces no single ideology or theory concerning the nature of dysfunctions related to alcohol or drug abuse; that it provides training in early intervention and treatment along a continuum; and that it provides trainees with highly individualized opportunities to develop competitive grant applications and by doing so, contribute new knowledge to the base of alcohol-related dysfunction and treatment. The training experience is structured to provide individualized research experience and training, complemented by a common academic curriculum to which fellows' allocated 20% of their training time. Four distinct areas are covered in the curriculum: (1) statistics/research methodology; (2) grantsmanship; (3) ethical issues in research; and (4) a two-year sequence of formal courses covering the etiology and treatment of hazardous drinking and alcohol use disorders from varying disciplinary perspectives. We also subscribe to a research apprenticeship model under the guidance of the research mentor. The fellow's individual research training experience emerges from an individualized development plan (IDP) developed by the fellow and agreed to by his/her mentors, and reviewed and approved by the Training Committee. The program has a primary emphasis on training in innovative treatment development and clinical trials with a secondary emphasis on the translation of clinical efficacy research into services, effectiveness, and cost- effectiveness research. Our didactic and research experiences in neurobiology and neuroimaging, behavioral genetics, and alcohol administration have expanded our focus of translational research from basic to clinical research. The expected training program duration is two years but on occasion we extend this training period to three years. We offer 3rd years for fellows with less extensive training in research methods; fellows who are cross-training, e.g. adding HIV/AIDS training to a primary background in alcohol research; or for fellows in each cohort who need more time to accomplish their goals of becoming independent investigators. The program has been accepting on average 3 to 4 new fellows per year. At any given time there are likely to be 9 to 10 fellows in residence. However, in order to comply with the $500K budget cap, we are requesting funding for a total of 8 fellows at this time. This is a reduction from the 10 of previous segments of this Training Program.