Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

摘要 这是莱亚·T博士的K24奖申请书格林伯格是密歇根大学的神经病理学家， 加州，旧金山弗朗西斯科（加州大学旧金山分校）。格林伯格是一个副教授在驻地和共同领导的 加州大学旧金山分校/记忆和衰老中心的神经病理学核心。她是这个病人的资深研究员- 面向痴呆症的临床研究。她的研究的一个显著特点是她直接参与了 创建，管理和分析属于人的具有良好特征的死后大脑集合- 有痴呆症的风险或已经患有痴呆症。Grinberg博士建议使用K24专用时间来指导USCF以及 国际研究人员在以病人为导向的痴呆症研究。她的学员将获得实践研究 经验，年龄相关的人类神经病理学的专业知识，数据分析培训，手稿准备， 和写作，以及职业生涯，指导。学员培训将利用基础设施和资源 加州大学旧金山分校/记忆和衰老中心尸检计划，这是正在进行的纵向队列研究的一部分， （P50 AG 02350和P01 AG 019724），以及她与多学科研究人员在以下领域的合作： 国内和世界范围内的痴呆症。为了提高她的指导技能，她建议参加 UCSF导师发展计划。格林伯格博士打算进行K24支持的阿尔茨海默病 研究将作为学员的培训工具，并扩大她的研究。这些研究， 使用临床、遗传和神经病理学数据，将使用正在进行的UCSF/Memory数据进行 和老龄化中心的NIH资助的阿尔茨海默病（AD）患者队列研究。她将检查 最近描述的神经退行性变化在改变AD临床表型中的作用。总的来说， K24将加强Ginberg博士在UCSF的广泛基础设施的积极研究计划，以支持 她的目标是保持在神经退行性疾病，特别是在神经病理学领域的领导者， 制定一个卓越的计划，培训医学生，实习生和初级教师在POR有关， 年龄相关的神经病理学，也旨在弥补神经病理学中断造成的差距 为神经科医生提供培训，为神经病理学家提供神经变性疾病培训。

ABSTRACT This is an application for a K24 award for Dr. Lea T. Grinberg, a neuropathologist at the University of California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient- oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in creating, managing and analyzing well-characterized postmortem collections of brains belonging to people at- risk or already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as international investigators in patient-oriented dementia research. Her mentees will gain hands-on research experience, expertise in age-related human neuropathology, training in data analysis, manuscript preparation, and grant writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources of the UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies (P50AG02350 and P01AG019724), and her collaborations with multidisciplinary researchers in the areas of dementia domestically and worldwide. To increase her mentoring skills, she proposes to participate in the UCSF Mentor Development Program. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease research studies that will serve as training vehicles for mentees and expand her research. These studies, using clinical, genetic and neuropathological data, will be conducted using data from ongoing UCSF/Memory and Aging Center's NIH-funded cohort studies of persons with Alzheimer's disease(AD) . She will examine the role of recently described neurodegenerative changes in modifying the clinical phenotype of AD. In summary, this K24 will enhance Dr. Ginberg's active research program with extensive infrastructure at UCSF to support her goal to remain a leader in neurodegenerative diseases, especially in the field of neuropathology, and to develop a program of excellence for training medical students, trainees, and junior faculty in POR related to age-related neuropathology that is also intended to close the gaps caused by interruption of neuropathology training for neurologists and neurodegenerative disease training for neuropathologists.