Training In Orthopaedic Team Science

 描述（由申请人提供）：基因组学、细胞生物学和生物医学工程技术的新知识爆炸已经成熟，可以转化为新的骨科应用，以改善肌肉骨骼疾病患者的诊断和管理。骨科研究项目一直缓慢地利用这一机会，因为在这一学科的固有结构性障碍，这使得越来越远的骨科医生和基础科学家在追求转化研究项目。在这个应用程序中，我们提出了一个新的范式，用于培训肌肉骨骼科学家在学术环境中，这是仿照制药公司使用的经过验证的团队科学方法。骨科团队科学培训（TOTS）计划将资助由骨科住院医师、博士后博士和博士后组成的发现团队进行严格限制的转化研究项目。研究员、医学院学生和教师。学员将完成核心课程，旨在提供肌肉骨骼病理生物学和临床研究执行基础的共同基础。研究和教学阶段的学习经验将同时发生的学员，以确保基础和临床团队成员之间的不断互动。一个丰富的计划将促进学员和教师之间的互动，并提供有价值的职业发展培训。TOTS指导委员会将监督项目和团队选择过程，并使用评估短期和长期措施的工具评估该计划的绩效。内部监督委员会将对该计划进行独立的持续评估，并将协调学员，培训计划教师和外部咨询委员会的反馈。TOTS计划的成功实施预计将产生肌肉骨骼科学家，他们将进入劳动力市场，在转化研究和领导力培训方面拥有必要的经验，从而有效地在工作台和床边之间移动发现。

 DESCRIPTION (provided by applicant): The explosion of new knowledge in genomics, cell biology and biomedical engineering technology is ripe for translation into new orthopaedic applications for improving the diagnosis and management of patients with musculoskeletal disorders. Orthopaedic research programs have been slow to capitalize on this opportunity because of inherent structural impediments in this discipline, which have increasingly distanced orthopaedic surgeons and basic scientists in the pursuit of translational research projects. In thi application, we propose a new paradigm for training musculoskeletal scientists in an academic setting, which is modeled after the proven, team science approach used by pharmaceutical companies. The Training in Orthopaedic Team Science (TOTS) program will sponsor the pursuit of well circumscribed, translational research projects by discovery teams composed of orthopaedic residents, post-doctoral Ph.D. fellows, medical students and faculty preceptors. Trainees will complete a Core Curriculum designed to provide a common grounding in musculoskeletal pathobiology and fundamentals in clinical research execution. Both research and didactic phases of the learning experience will occur concurrently by the trainees to ensure constant interaction between basic and clinical team members. An Enrichment Program will catalyze interactions between trainees and faculty and provide valuable career development training. The TOTS Steering Committee will oversee the project and team selection process, and evaluate the program's performance using tools for assessing short and long-term measures. An Internal Oversight Committee will provide independent, ongoing evaluation of the program and will coordinate feedback from trainees, training program faculty, and an External Advisory Committee. Successful implementation of the TOTS program is expected to produce musculoskeletal scientists who will enter the workforce with the requisite experience in translational research and leadership training to move discoveries effectively between the bench and bedside.