DC Partnership for HIV/AIDS Progress (DC PFAP)

在过去的一年里，DC PFAP在以下领域取得了重大进展 1. DC队列数据库已入组9000多例患者。 该计划正在所有研究中心注册。 数据分析师正在研究合并数据。该数据库为城市艾滋病毒感染者提供独特的、真实的时间粒度。 这些数据与DC卫生部数据库相结合，以提高其分析城市流行病的实用性。摘要和手稿正在进行中。 2. 预防方案在招募非裔美国人男性和女性参与研究以评估其风险行为方面超出了预期。 基于受试者的上级入组和保留，DC研究者已被邀请参与PREP研究，DC研究中心在入组和保留随访方面处于领先地位。 3.所有进行的研究都是由医生发起的研究，几乎只在该市服务不足的人群中招募。在过去三年中完成的研究包括在艾滋病毒感染和未感染患者中进行的各种联合治疗方案的独特研究。该计划侧重于以科学为基础的研究，研究组织和血液中的作用机制和反应相关性。 此外，还完成了一项雄心勃勃的研究，以确定初级保健提供者是否可以安全有效地提供DAA治疗。这项研究已经在主要会议上提出，并引起了高度的兴趣，因为它表明，能够治疗HCV的供应商的池可能比单独的亚专家大得多。该研究将于2017年第四季度提交出版 4.该方案与为性工作者、有非法使用药物问题和患有性传播疾病的客户提供服务的诊所建立了新的关系。新的研究题为重力，停止和锚将探讨方法，以确定事件的情况下，新承认的流行病例。目标是为哥伦比亚特区设计一个“零排放”战略。 该项目正在提前完成其所有任务。该计划正在与DC艾滋病研究中心以及社区和学术合作伙伴有效合作，以在DC建立一个强大的艾滋病研究网络。

During this past year DC PFAP has made substantial progress in the following areas 1. The DC Cohort database has over 9000 patients enrolled. The program is enrolling at all sites. Data analysts are looking at merged data. This database is providing unique, real time granularity for the city HIV population. The data is meshed with the DC Department of Health database to enhance its utility for analyzing the city epidemic. Abstracts and manuscripts are in progress. 2. The prevention protocols have exceeded expectations in terms of enrolling African American men and women in studies to assess their risk behavior. Based on superior enrollment and retention of subjects, the DC investigators have been invited to participate In PREP studies have been completed with DC sites being among the leaders in enrollment and retention in follow up. 3. All studies performed are investigator-initiated studies, which recruited almost exclusively among the citys underserved populations. Studies completed in the past three years have included unique studies of various combination regimens in HIV infected and uninfected patients. The program has focused on science-based studies looking at mechanisms of action and correlates of response in tissue and in blood. Also completed was an ambitious study to determine whether primary care providers could deliver DAA therapy safely and effectively. This sudy has been presented at major meetings and has engendered a high level of interest since it suggests that the pool of providers capable of treating HCV could be much larger than subspecialists alone. This study will be submitted for publication in the fourth quarter of 2017 4. The program has established new relationships with clinics that serve clients who are sex workers, who have illegal substance use issues and who have sexually transmitted diseases. New studies entitled GRAVITY, CEASE and ANCHOR will explore methods to identify incident cases and newly recognized prevalent cases. The goal is to design a Getting to Zero strategy for the District of Columbia. This project is fulfilling all of its missions ahead of schedule. The program is working effectively with the DC Center for AIDS Research and with community and academic partners to build a strong AIDS research network in DC.