Aspen Lung Conference: Environment and Global Lung Health, Susceptibility, and Intervention

项目总结/摘要 第60届托马斯L. 小白杨肺会议将集中在一个中心问题：如何知识的机制， 将潜在的肺损伤引起的慢性肺部疾病转化为有效的治疗方法， 最终预防这些肺部疾病的负担？为了解决这个核心问题，我们组织了 该计划分为一系列主题会议，重点关注（i）暴露引起的严重程度和负担 肺部疾病以及这些慢性疾病对全球健康的影响（ii）接触评估 暴露生物学和易感宿主，（iii）导致纤维化的暴露分子机制， 哮喘和其他慢性肺部疾病，（iv）表观遗传、遗传和基因组与环境的相互作用， 导致阻塞性肺病、癌症和肺纤维化，以及（v） 预防和干预的科学进步，以减少暴露和改善肺部健康。通过解决这些 我们将在五个专题会议上讨论所有主题，力求实现以下目标： 1)为领先的基础，转化和临床研究人员提供一个国际论坛，以交流 关于暴露和易感性的贡献的基本概念的想法 慢性肺部疾病的发展。 2)为了促进暴露生物学、分子生物学、表观遗传学、 遗传学、基因组学和公共卫生，目标是确定新出现的共同利益， 导致更有效和富有成效的研究的表现。 3)提高将临床前科学进展成功转化为直接患者的可能性 通过制定新的战略，更好地实施治疗和减少艾滋病毒/艾滋病方面的科学进步， 在全球范围内提高肺部健康。 4)挑战和激发学员的科学兴趣，吸引新一代的年轻人 研究人员对吸烟引起的肺部疾病和全球健康领域的研究。

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational and clinical approaches, the 60th annual Thomas L. Petty Aspen Lung Conference will focus on a central question: how can knowledge of the mechanisms underlying exposure-induced chronic lung diseases be translated into effective approaches to treat and ultimately prevent the burden of these lung diseases? To address this central question, we have organized the program into a series of thematic sessions focusing on (i) the magnitude and burden of exposure-induced lung diseases as well as the impact these chronic diseases are having on global health (ii) exposure assessment , exposure biology and the susceptible host, (iii) the molecular mechanisms of exposure that result in fibrosis, asthma and other chronic lung diseases, (iv) epigenetic, genetic, and genomic interactions with the environment, resulting in obstructive lung disease, cancer, and pulmonary fibrosis and (v) strategic approaches to translate scientific advances to prevent and intervene to reduce exposures and improve lung health. By addressing these topics across five thematic sessions, we seek to accomplish the following objectives: 1) To provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding fundamental concepts regarding the contribution of exposure and susceptibility to development of chronic lung disease. 2) To stimulate interactions between the scientific fields of exposure biology, molecular biology, epigenetics, genetics, genomics and public health with the goal of identifying emerging, shared interests that may lead to the performance of more efficient and productive research. 3) To enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better implement scientific advances in treatment and reduction in exposures to enhance lung health globally. 4) To challenge and stimulate the scientific interests of trainees, attracting a new generation of junior investigators into the field of exposure-induced lung disease and global health.