Mentoring Translational Research in HIV

项目摘要 本申请是Davey Smith博士的K24资助项目“指导转化研究”的更新建议 在艾滋病中。迄今为止，这笔赠款支助了30多名受训人员的培训和80份出版物。虽然显著 尽管艾滋病毒研究继续取得进展，但不太可能找到安全有效的艾滋病毒治疗方法或疫苗。 很快就会开发出来。这些目标的成功将取决于未来的艾滋病毒研究人员，其中许多人是 可能在未来五年内接受培训。 本K24提案的目标是为Smith博士提供足够的支持，以指导最先进的培训人员 翻译和病人为导向的艾滋病毒研究，并扩大他在加州大学圣地亚哥分校的广泛的培训参与 程序.此应用程序是建立在资助和正在进行的研究项目，其中学员是主要的 领导者，并在研究设计、执行、分析、结果解释和出版的各个方面接受培训。 所提出的研究提供了机会，深入指导，以及调查的重要和 艾滋病发病机制的科学问题。这些目标将在以下三个目标中实现， 初级和高级受训人员。 具体目标1：确定合并感染如何影响HIV发病机制。 具体目标2：开发和验证新的分子病毒学技术。 具体目标3：使用分子流行病学方法为艾滋病毒预防提供信息。

Project Summary This application is a proposed renewal of Dr. Davey Smith's K24 grant entitled `Mentoring Translational Research in HIV'. This grant supported the training of over 30 trainees and 80 publications to date. While significant progress in HIV research continues to be made, it is not likely that a safe and effective cure or vaccine for HIV will be developed soon. The success of these goals will depend on future HIV researchers, many of whom are likely to be trained in the next five years. The goal of this K24 proposal is to provide Dr. Smith with sufficient support to mentor trainees in state-of-the-art translational and patient oriented HIV research and to expand his involvement in UCSD's wide array of training programs. This application is built upon funded and ongoing research projects, where the mentee is the primary leader and is trained in every aspect of study design, execution, analyses, results interpretation and publication. The presented studies provide opportunities for in-depth mentoring as well as investigation into important and open scientific questions in HIV pathogenesis. These goals will be met in the following three aims with a core group of junior and senior trainees. SPECIFIC AIM 1: To determine how co-infections impact HIV pathogenesis. SPECIFIC AIM 2: To develop and validate new molecular virology technology. SPECIFIC AIM 3: To use molecular epidemiologic methods to inform HIV prevention.