Mentoring in Patient-Oriented Neuroscience Research

项目摘要 我是一名临床研究员，也是成瘾和心理健康神经发育实验室的主任。 在姆克林医院我也是哈佛医学院的精神病学副教授。我一直在 作为主要研究者（PI）持续资助进行NIAAA赞助的以患者为导向的研究 (POR)自2004年以来，他一直是NIH赞助的几项额外赠款的合作者和顾问。 我的研究重点是了解青少年的大脑发育， 成瘾和精神疾病的神经生物学。我目前担任PI的一个NIAAA R01赠款和一个 基金会赠款，并在3 R01（NIMH，NCCAM，NIDA）和1 R21（NIAAA）的共同研究员。我指导一个 不断壮大的初级研究人员队伍，包括3名K01赠款学员。我在一个富裕的环境中工作， 临床研究，这是理想的培训初级教师在POR。然而，我没有得到任何机构的支持， 指导，并将被要求削减指导工作，以承担重大的非研究责任 从2017年开始K24奖将保护时间，这将允许增加密集的指导， 初级调查员和吸引研究人员到POR。我的近期和长期职业目标是 描述成瘾和精神疾病的神经生物学标志物，这将为开发 为酒精使用障碍和双重诊断患者提供新的有效治疗方法，并培训 培养下一代调查人员，以培养他们有效开展POR所需的技能。我也依然 致力于传播研究成果（通过出版物、科学讲座和公共宣传）， 这将有助于预防工作，并将为治疗干预提供信息，以帮助减少因 酒精使用和滥用。在授予期间要实现的具体目标是：1）提供 对POR中的初级调查员进行实质性指导（35%），2）继续并扩大参与我的POR (10%），以及3）在青少年共病精神病理学领域开发特定的新内容专业知识， 青少年治疗环境中的临床方法和表观遗传学（5%）。我致力于培养一个 一群杰出的学员，他们是成瘾和精神病学的未来。通过密集 反过来，我将通过增加我的临床观点和结合 治疗和表观遗传成分纳入新的POR计划。

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on several additional NIH-sponsored grants. My research has focused on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. I currently serve as PI on one NIAAA R01 grant and one Foundation grant, and am Co-Investigator on 3 R01s (NIMH, NCCAM, NIDA) and 1 R21 (NIAAA). I mentor a growing group of junior investigators, including 3 mentees on K01 grants. I work in a rich environment for clinical research, which is ideal for training junior faculty in POR. However, I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non-research responsibilities beginning in 2017. The K24 award will protect time that would permit an increase in intensive mentorship to junior investigators and attract researchers to POR. My immediate and long-term career objectives are to characterize neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for patients with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I also remain committed to disseminating research findings (through publications, scientific lectures and public outreach) that will help prevention efforts and that will inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators in POR (35%), 2) continue and extend involvement in my POR (10%), and 3) develop specific new content expertise in the areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment settings, and epigenetics (5%). I am committed to training a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will, in turn, enhance my POR by increasing my clinical perspectives, and by incorporating treatment and epigenetic components into new POR initiatives.