P30-Center Core Grant for Vision Research

摘要 总括 此续订申请的目标是管理和维护现有的核心设施，这些设施将提供 为22个独立视力研究实验室提供技术支持、设备准入和人员培训 俄克拉荷马大学健康科学中心。我们有三个利用率很高且成功的核心：LIVE 动物成像和功能分析(LAI)、细胞成像和形态测量分析(CIC)以及 基因分型(GTC)。LAI核心(两个独立的模块)位于两个主要模块的内部 Varia是校园里大多数视力研究动物的栖息地(一个SPF设施主要用于 繁育)。每个核心由NEI R01资助的调查员指导，并由高资质和 训练有素的系统经理，协助和培训视觉研究人员使用最先进的 资源。可获得多种类型的先进设备、复杂的软件和“实际操作” 培训极大地提高了我们的用户研究成果的质量和数量 愿景核心设施。这些核心具有：1)增加了严格翻译研究的机会，使用 临床相关的非侵入性成像程序，2)生成的协作项目需要 多个专业领域，3)从而提高了现有研究项目的生产率 允许参与的研究人员在资金方面保持竞争力，4)促进了新教师的招聘 来自其他校园，以及5)支持基于收购的新研究战略的开发 来自使用设备的数据，否则私人投资机构无法获得。

ABSTRACT Overall The goals of this renewal application are to manage and maintain existing core facilities that will provide technical support, equipment access, and personnel training for 22 independent vision research laboratories at the University of Oklahoma Health Sciences Center. We have three highly utilized and successful cores: Live Animal Imaging and Functional Analysis (LAI), Cellular Imaging and Morphometric Analysis (CIC), and Genotyping (GTC). The LAI core (two independent modules) is conveniently located inside of the two major vivaria that houses most of the vision research animals on campus (an SPF facility is used primarily for breeding). Each core is directed by an NEI R01-funded investigator and supervised by a highly qualified and well-trained Systems Manager who assists and trains vision researchers in the use of state-of-the-art resources. The availability of multiple types of advanced equipment, sophisticated software, and "hands on" training has dramatically increased the quality and quantity of research achievements by the users of our Vision Core facilities. These cores have: 1) increased opportunities for rigorous translational research using clinically relevant and non-invasive imaging procedures, 2) generated collaborative projects that require multiple areas of expertise, 3) increased and enhanced productivity of existing research projects thereby allowing participating investigators to remain competitive for funding, 4) promoted recruitment of new faculty from other campuses, and 5) supported the development of new research strategies based on the acquisition of data from the use of equipment otherwise unavailable to the PIs.