Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress

该项目通过以下方式与NIEHS的战略目标保持一致：1）包括调查综合环境暴露如何影响疾病发病机制; 2）提高对共同生物途径的理解，在这种情况下，氧化应激是这些暴露影响的基础; 3）调查怀孕期间的暴露如何影响儿童的早期生命发展。该项目是今年启动的，因此迄今没有任何出版物。然而，自从1月份开始在NIEHS工作以来，我已经在数据收集方面迈出了几步。首先，根据自由基代谢组（免疫、炎症和疾病分支）研究者的意见，我已经建立了将用于尿液样本氧化应激分析的实验室，并且正在等待唯一的来源依据。其次，我与合作者托马斯McElrath博士优化了一个医疗记录摘要表，以从TIDES参与者那里获得关于特定分娩结果的额外信息。第三，我已经获得IRB批准，可以修改从西奈山伊坎医学院提取的数据。我现在正在与TIDES研究小组在四个单独的研究中心合作，以获得对那里的修改的批准。最后，我获得了NIEHS的豁免，以便我可以使用从研究中收集的数据。在接下来的一年里，我预计会收到关于尿氧化应激生物标志物、病历数据和妊娠晚期尿邻苯二甲酸酯代谢物的数据，并将开始分析数据并发表本研究的结果。

This project aligns well with the strategic goals of NIEHS by: 1) Including investigation of how combined environmental exposures impact disease pathogenesis; 2) Improving understanding of a shared biological pathway, in this case oxidative stress, underlying the impact of these exposures; and 3) Investigating how exposures during pregnancya critical window of susceptibilityrelate to the early life development of the child. This project was initiated this year, and thus does not have any publications to date. However, since beginning my position at NIEHS in January, I have made several substantial steps toward data collection. First, with input from investigators in the Free Radical Metabolism Group (Immunity, Inflammation, and Disease Branch), I have established the laboratory that will be utilized for oxidative stress analyses in urine samples and have a sole source justification pending. Second, I optimized a medical record abstraction form with collaborator Dr. Thomas McElrath to obtain additional information from TIDES participants on specific delivery outcomes. Third, I have received IRB approval for a modification to abstract this data from the Icahn School of Medicine at Mount Sinai. I am now working with the TIDES study team at the four individual study sites to obtain approval for the modifications there as well. Lastly, I have obtained an exemption from NIEHS so that I may utilize the data collected from the study. During the next year I anticipate receiving data on urinary oxidative stress biomarkers, medical record data, and urinary phthalate metabolites from the third trimester of pregnancy, and will begin analyzing data and publishing the results from this study.