NIAMS Multidisciplinary Clinical Research Center

描述(由申请人提供)：响应2012年医学研究所报告中的紧急行动呼吁。慢性病患者的健康生活：呼吁采取公共卫生行动 根据2010年国家骨关节炎公共卫生议程(NPHAOA)，本申请建议在北卡罗来纳大学(UNC)瑟斯顿关节炎研究中心(TARC)建立一个新的多学科临床研究中心(MCRC)，题为减轻骨关节炎对公共卫生的影响。拟议的MCRC汇集了多个新的OA研究单位和研究人员，以建立新的合作关系，其长期目标是：1)了解与OA的发展和进展及其导致的残疾相关的病因因素；2)确定最佳实践，为社区采用关键的公共卫生建议提供信息，以防止这些结果的发生和进展；以及3)通过作为创新、培训和合作的枢纽，改变北卡罗来纳大学园区的OA研究的面貌。NPHAOA建议解决关节损伤预防、增加体力活动、体重控制和关节炎自我管理教育，以减缓这场迫在眉睫的公共健康危机。MCRC将以这些主题为重点，利用两项独特的北卡罗来纳大学研究：1)约翰斯顿县OA项目，这是北卡罗来纳州非裔美国人和白人男性和女性的OA和残疾的20多年预期队列，以及2)JUMP-ACL，这是一个研究男性和女性军校学员膝关节损伤的独特队列，其中有受伤前的生物力学数据和生物标本。项目1涉及伙伴支持在启动和维持缺乏活动的骨质疏松症患者增加体力活动方面的作用背后的基本机制。项目2考察了生物力学和生物标记物在预测膝关节损伤和损伤介导性骨性关节炎发展中的关系。方法学核心是核心，将支持2个拟议的项目和与NIAMS使命相关的其他多个现有项目，并将促进新的研究，并向下一代关节炎研究人员提供研究方法和指导方面的培训。由执行委员会和内部和外部咨询委员会组成的行政核心将为中心提供支助。通过将我们的老牌研究人员与新的体力活动专业知识结合在一起 这一充满活力的中心，包括生物测量、生物力学和生物标记物，以及新培训的年轻研究人员，将推动公共卫生OA议程，并为实施未来治疗和预防OA及其后果的干预措施奠定基础。

DESCRIPTION (provided by applicant): Responding to an urgent call to action from the 2012 Institute of Medicine report. Living Well with Chronic Illness: A call for public health action and the 2010 National Public Health Agenda for Osteoarthritis (NPHAOA), this application proposes a new Multidisciplinary Clinical Research Center (MCRC) at the Thurston Arthritis Research Center (TARC) at the University of North Carolina (UNC), entitled Mitigating The Public Health Impact of OA. The proposed MCRC draws together multiple units and investigators new to OA research into novel collaborative relationships with the long-term goals of: 1) understanding the etiologic factors associated with development and progression of OA and Its resultant disability; 2) Identifying best practices to Inform adoption of critical public health recommendations in communities to prevent the occurrence and progression of these outcomes, and 3) transforming the face of OA research on the UNC campus by serving as a hub for Innovation, training, and collaboration. The NPHAOA recommends addressing joint injury prevention, increased physical activity, weight control, and arthritis self-management education to slow this looming public health crisis. This MCRC will use these themes as its focus and leverages 2 distinctive UNC studies: 1) the Johnston County OA Project, a 20+ year prospective cohort of OA and disability in African American and White men and women in NC, and 2) JUMP-ACL, a unique cohort studying knee injury in men and women military cadets in whom pre-injury biomechanics data and biological specimens are available. Project #1 addresses basic mechanisms behind the role of partner support in the initiation and maintenance of increased physical activity in insufficienty active people with OA. Project #2 examines the relationship between biomechanics and biomarkers in predicting knee injury and development of injury-mediated OA. The Methodology Core is central and will support the 2 proposed projects and multiple other extant projects relevant to the mission of NIAMS and will foster new research and provide training in research methodology and mentoring to the next generation of arthritis researchers. An Administrative Core with an Executive Committee and Internal and External Advisory Boards will support the Center. By bringing together our established investigators with new expertise in physical activity measurement, biomechanics, and biomarkers, and newly trained young investigators, this vibrant center will advance the public health OA agenda and lay the foundation for implementing future interventions to treat and prevent OA and its consequences.