Air Quality and Reproductive Health

在美国，空气污染物导致发病率和死亡率上升，据估计，每年有13.5万人因臭氧和2.5微米/立方米的颗粒物而过早死亡。空气质量差还与不良妊娠结局有关，包括早产、胎儿生长受限/出生体重低和婴儿死亡率。本项目审查与生育率和分娩/分娩数据有关的空气质量措施，以补充与接触空气污染物有关的生殖健康结果的文献。

Air pollutants cause increased morbidity and mortality in the US, with an estimated 135,000 premature deaths due to ozone and particulate matter of 2.5 microns/cubic meter each year. Poor air quality has also been associated with adverse pregnancy outcomes including preterm delivery, restricted fetal growth/low birth weight and infant mortality. This project examines air quality measures in relation to fertility and labor/delivery data to add to the literature on reproductive health outcomes associated with air pollutant exposures. Of particular interest are pregnancy outcomes for women with asthma, who may represent a vulnerable subgroup for the combined effects of poor air quality and asthma-related health effects and the novel assessment prospective time-to-pregnancy associated with exposure to traffic and monitored air quality. Most prior studies of air pollution and pregnancy outcomes have been based on vital record data. This project represents an opportunity to evaluate labor and delivery complications on a broad national level and fertility measures that have not been previously studied. Exposure assessment is based on Community Multiscale Air Quality models. Secondary outcomes, including cardiovascular complications in labor/delivery, gestational diabetes, and birth defects are also addressed in relation to air quality and ambient temperature.