B-WELL-Mom Study

西北大学和阿拉巴马大学伯明翰大学的B-Well-Ma临床中心将从他们的产前诊所招募总共400名哮喘患者(200名哮喘控制良好，200名哮喘控制不佳)和150名没有哮喘的女性。哮喘控制评估将基于NHLBI专家小组报告中描述的标准。除哮喘史问题外，对照组受试者遵循相同的方案。所有患者将接受四次研究诊所的访问。在每次就诊时，临床评估将包括血压、脉搏血氧饱和度、峰值流量、FEV1和FEV6。还将收集生物标本。患者完成与哮喘加重或缓解或呼吸问题的症状和风险因素有关的问卷调查。将进行流式细胞术来计数包括T调节细胞在内的免疫细胞。所有的临床数据收集程序都是风险最低的既定程序，研究调查基于预先存在的有效问卷。在就诊期间，女性将记录她们的峰值流量，呼出一氧化氮，并回答有关症状、药物和其他可能干扰呼吸的因素的问题。医疗记录审查将包括急诊和住院以及分娩和分娩的细节。

The B-WELL-Mom clinical centers, Northwestern University and the University of Alabama Birmingham, will recruit a total of 400 asthmatics (200 with well-controlled asthma and 200 with sub-optimal asthma control) and 150 women without asthma from their prenatal clinic populations. Asthma control assessment will be based on the criteria described in the NHLBI expert panel report. Except for asthma history questions, control subjects follow the same protocol. All patients will have four study clinic visits. At each visit, clinical assessments will include blood pressure, pulse oximetry, peak flow, FEV1 and FEV6. Biologic specimens will also be collected. Patients complete questionnaires related to symptoms and risk factors for exacerbation or mediation of asthma or breathing problems. Flow cytometry will be conducted to count immune cells including T-regulatory cells. All of the clinical data collection procedures are well-established procedures with minimal risk and the study surveys are based on preexisting, validated questionnaires. Between clinic visits, women will record their peak flow, exhaled nitric oxide and answer questions on symptoms, medications and other factors that might interfere with breathing. Medical record review will capture emergency visits and hospitalizations as well as details of labor and delivery.