Pre-doctoral Training Program in Integrative Vascular Biology

程序摘要 心血管疾病的复杂性阻碍了我们对其发展和进展的理解。 揭示遗传变异和环境因素影响的机制 心血管发展和疾病，下一代科学家将需要接受培训，使用 各种方法、技术和模型系统。为了满足这一需求， 生物学（IVB）博士前培训计划成立于2002年，以促进合作 为心血管领域的博士前学生提供跨学科的培训环境。IVB计划 结合了心血管研究学院的广度和深度与其他研究优势， 遗传模型系统，最先进的细胞生物学和成像，高通量基因组学和蛋白质组学 分析和计算生物学。IVB计划的总体目标是为学员提供 必要的跨学科和协作技能，将他们的论文工作扩展到新的，创新的， 生产方向。具体目标1是在心血管研究的广泛领域联系学员 通过要求他们与他们领域之外的二级导师合作。这种培训机制是 专门设计用于“连接”心血管生物学广泛领域的研究生， 心血管健康研究。该计划教学生应用分子，细胞，遗传， 细胞、器官和整个动物的病理和生理问题的计算方法 系统;合并假设和发现为基础的研究;并开发高通量的方法， 用于复杂的模型。具体目标2是为学员提供对心血管疾病的广泛理解 发展和疾病。这将通过先进的纸质心血管课程来实现， 由该领域的领导人举办心血管研讨会，并通过双周一次的学生领导的讨论小组。具体 目标3是提高有效合作和职业发展所需的技能。学员将 通过在正式和非正式的IVB活动中展示他们的作品来提高他们的沟通技巧，学生将 参加IVB研讨会，讨论拨款写作、职业发展和科学严谨性和责任感。IVB 该计划由麦卡利斯特心脏研究所管理，并由Christopher Mack博士（助理）指导 病理学教授）是一位受人尊敬的血管生物学家， 多层次的培训。他是由共同主任Nobuyo Maeda（病理学教授）和Vicki协助 鲍奇（生物学教授）和执行和咨询委员会的建议，由良好的- 资深血管生物学家该计划的一个主要优势是39个项目的广度和多样性。 初级培训教师谁致力于研究生培训，谁是使用尖端 方法来回答各种各样的心血管问题。总而言之，凭借出色的历史， 心血管生物学研究，一个强大的研究小组围绕MHI，一个发达的 心血管科学的学术课程，大量合格的申请人和研究 在遗传模型系统、细胞生物学和计算生物学方面的卓越成就， 生物学课程为博士前学生的多学科培训提供了良好的环境。

Program Abstract The complexity of cardiovascular disease has hindered our understanding of its deveopment and progression. To uncover the uncover the mechanisms by which genetic variation and environmental factors influence cardiovascular development and disease, the next generation of scientists will need to be trained to use a variety of approaches, technologies and model systems. In response to this demand the Integrative Vascular Biology (IVB) Pre-doctoral Training Program was established at UNC in 2002 to promote a collaborative interdisciplinary training environment for pre-doctoral students in the cardiovascular field. The IVB Program combines the breadth and depth of the cardiovascular research faculty with other research strengths at UNC in genetic model systems, state-of-the-art cell biology and imaging, high throughput genomic and proteomic analyses, and computational biology. The overall goal of the IVB Program is to provide Trainees with the interdisciplinary and collaborative skills necessary to extend their thesis work into new, innovative, and productive directions. Specific Aim 1 is to connect Trainees in broad areas of cardiovascular research by requiring them to collaborate with secondary mentors outside of their field. This training mechanism was specifically designed to “connect” graduate students in broad areas of cardiovascular biology and cardiovascular health research. The program teaches students to apply molecular, cellular, genetic, and computational approaches to pathological and physiological questions in cell, organ, and whole animal systems; to merge hypothesis- and discovery-based research; and to develop high-throughput approaches for use in complex models. Specific Aim 2 is to provide Trainees with a broad understanding of cardiovascular development and disease. This will be achieved through advanced paper-based cardiovascular courses, cardiovascular seminars by leaders in the field, and through bi-weekly student-led discussion groups. Specific Aim 3 is to enhance the skills necessary for effective collaboration and career advancement. Trainees will improve their communication skills by presenting their work at formal and informal IVB events and students will attend IVB Workshops on grant writing, career development, and scientific rigor and responsibility. The IVB Program is administered by UNC McAllister Heart Institute and is directed by Dr. Christopher Mack (Associate Professor of Pathology) a respected vascular biologist who has been heavily involved in graduate student training at multiple levels.. He is assisted by Co-directors Nobuyo Maeda (Professor of Pathology) and Vicki Bautch (Professor of Biology) and by the advice of executive and advisory committeees made up of well- established senior vascular biologist. A major strength of the Program is the breadth and diversity of the 39 primary training faculty who are committed to graduate student training and who are using cutting edge approaches to answer a wide variety of cardiovascular questions. In summary, with an outstanding history in cardiovascular biology research, a strong group of investigators centered around the MHI, a well-developed academic program in Cardiovascular Science, a large pool of well-qualified applicants, and research excellence in genetic model systems, cell biology, and computational biology, the UNC Integrative Vascular Biology Program offers an outstanding environment for multidisciplinary training of pre-doctoral students.