Serial Nights of Alcohol Administration: Impact on Sleep and Next-Day Neurocognitive Function and Alertness

摘要摘要 考虑到美国酒精问题的范围，我们的跨学科团队联合了两个 不同的科学观点来研究酒精和睡眠与神经认知能力和 这种互动是否有助于确定改善酒精使用障碍治疗结果的策略 (澳元)。AUD心理社会治疗已经开发出跨越许多方法，但所有这些 干预依赖于完整的认知功能才能有效。神经认知功能的多个方面 然而，需要学习和应用心理社会技能的人会受到反复饮酒和 睡眠障碍。有效地使用心理治疗传授的技能需要神经认知功能 与1)学习技能、2)提前和即时评估技能需求和3)保持一致 在需要时实施技能。持续大量饮酒和相关睡眠的组合 干扰可能会阻止患者实现有效的心理社会干预的全部好处。 在AUD和心理社会干预的背景下改善睡眠的方法必须针对以下方面 睡眠最能预示神经认知功能受损，尤其是在反复饮酒的情况下 使用。连续(即多夜)饮酒和睡眠中断的影响及其交互作用 对神经认知功能的影响尚不清楚。此外，人们明显缺乏酒精和睡眠-- 成熟成人(定义为35-50岁)的相关实验室研究，包括对潜在男女的评估 不同之处。我们的方法是测试成年大量饮酒的成年人的睡眠和第二天的神经认知影响 在受控实验室环境中连续晚上给予酒精(目标BAC为0.1g%)后 在三种睡眠状态下：正常睡眠(饮酒后按“正常睡眠时间表”睡眠8.5小时)、延迟睡眠 (饮酒后8.5小时睡眠比平时晚3小时)和延迟/受限(饮酒后5.5小时 比平时晚睡3小时)。这些研究条件提供了探索神经认知的机会 酒精对睡眠影响的后果，但也是为了追求基础研究问题。这些研究 将1)评估在3种睡眠条件下3晚饮酒的影响(名义、延迟、 延迟/受限)第二天的神经认知表现和警觉性/困倦；2)评估 夜间连续饮酒、酒精代谢率和3种睡眠状况之间的关系 和睡眠生理学；以及3)我们将探索睡眠和酒精变量对下一步的机械影响- 白天的神经认知功能。

Summary Abstract Given the scope of the alcohol problem in the US, our interdisciplinary team has come together with two distinct scientific outlooks to examine the interaction of alcohol and sleep with neurocognitive performance and whether this interaction may help identify strategies to improve treatment outcomes for alcohol use disorders (AUD). AUD psychosocial treatments have been developed that span a number of approaches, but all such interventions depend on intact cognitive function to be effective. Many aspects of neurocognitive function required to learn and apply psychosocial skills, however, are adversely affected by repeated alcohol use and sleep disturbance. Effective use of the skills taught by psychotherapy requires neurocognitive functioning consistent with 1) learning skills, 2) assessing the need for skills both ahead of time and in the moment, and 3) implementing skills when needed. The combination of continued heavy alcohol use and associated sleep disruption likely prevents patients' realizations of the full benefits of effective psychosocial interventions. Approaches to improving sleep in the context of AUD and psychosocial interventions must target aspects of sleep most predictive of impaired neurocognitive functioning, particularly under conditions of repeated alcohol use. The effects of serial (i.e., multi-night) alcohol administration and sleep disruption and their interactive effect on neurocognitive function are unknown. Furthermore, there is a notable lack of alcohol and sleep- related laboratory research in mature adults (defined as 35-50), including assessment of potential male-female differences. Our approach is to test sleep and next-day neurocognitive effects in mature heavy-drinking adults after administering alcohol (targeted BAC of .1g%) on consecutive nights in a controlled laboratory setting under three sleep conditions: nominal (drinking followed by 8.5 h sleep on “usual sleep schedule”), delayed (drinking followed by 8.5 h sleep 3 h later than usual sleep), and delayed/restricted (drinking followed by 5.5 h sleep 3 h later than usual). These study conditions provide the opportunity to explore neurocognitive consequences of alcohol's effects on sleep, but also to pursue fundamental research questions. These studies will 1) assess the influence of 3 nights' alcohol administration under 3 sleep conditions (nominal, delayed, delayed/restricted) on next-day neurocognitive performance and alertness/sleepiness; 2) assess the associations among serial nightly alcohol administration, rate of alcohol metabolism, and 3 sleep conditions and sleep physiology; and 3) we will explore sleep and alcohol variables for mechanistic influences on next- day neurocognitive functioning.