Center for Research on the Ethical, Legal and Social Implications of Psychiatric

描述（由申请人提供）：本申请书提议在哥伦比亚大学医学中心（CUMC）建立一个精神病学、神经病学和行为遗传学（PNB）的伦理、法律和社会影响研究中心。自2010年4月以来，我们获得了P20开发中心的资助，用于创建基础设施并开始开发这样一个中心。由于许多PNB疾病和特征的高度污名化性质，PNB遗传学呈现出特殊的伦理，法律和社会挑战；PNB疾病的遗传易感性和特征对行为责任认知的潜在影响；遗传倾向和环境影响之间复杂的相互作用决定了许多PNB疾病的发病和病程，使得许多PNB遗传数据的含义本质上是模糊的。我们的新中心将促进对PNB遗传学背景下出现的一系列问题的深思熟虑，并开发创新的方法来解决这些问题。具体来说，我们将开展一个重点研究项目，探索PNB遗传信息在个人、熟悉和社会层面的影响，考虑其对耻辱和自我形象、责任归因和对模糊性的反应的影响，以及系统地考虑我们的研究结果的更广泛的规范和政策含义。为了使我们的研究价值最大化，我们将建立健全的机制，利用其他专家和主要利益相关者团体的参与，将我们研究的经验和规范成果转化为政策和实践建议。着眼于ELSI研究的未来，我们将开发一个多学科的博士后培训计划，重点培养ELSI研究的未来领导者，创造一个促进跨学科学习和研究的环境，并吸引优秀的导师和教师。总之，我们将建立一个架构，以我们现有的优势和成就为基础，加强跨学科合作，促进创新研究的进行，并促进教师和学员之间的智力发展。

DESCRIPTION (provided by applicant): This application proposes the establishment of a Center for Research on the Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral (PNB) Genetics at Columbia University Medical Center (CUMC). Since April 2010, we have been funded under a P20 Developing Center grant to create the infrastructure and begin development of such a Center. PNB genetics present particular ethical, legal and social challenges because of the highly stigmatized nature of many PNB disorders and traits; the potential impact of genetic predispositions for PNB disorders and traits on perceptions of responsibility for behavior; and the complex interactions between genetic propensities and environmental influences that determine the onset and course of many PNB disorders, rendering the implications of many PNB genetic data inherently ambiguous. Our new Center will promote thoughtful consideration of the range of issues arising in the context of PNB genetics and develop innovative approaches to addressing them. Specifically, we will undertake a focused program of research that explores the impact of PNB genetic information at the individual, familiar and societal levels, considering its effects on stigma and self-image, attributions of responsibility, and responses to ambiguity, along with systematic consideration of the broader normative and policy implications of our findings. To maximize the value of our research, we will create robust mechanisms to translate the empirical and normative output of our research into recommendations for policy and practice, capitalizing on the involvement of other experts and key stakeholder groups. With an eye on the future of ELSI studies, we will develop a multidisciplinary post-doctoral training program focused on nurturing future leaders in ELSI research, creating an environment that facilitates cross-disciplinary learning and research and draws on outstanding mentors and teachers. In sum, we will create a structure that builds on our existing strengths and accomplishments to enhance transdisciplinary collaboration, facilitate the conduct of innovative research, and foster intellectual growth among both faculty and trainees.