Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT

摘要 骨微结构的病理变化与广泛的 肌肉骨骼(MSK)疾病，包括骨质疏松症(OP)和骨关节炎(OA)。OP和OA进位 巨大的医疗负担，估计有1000万美国成年人患有OP，2700万 患有骨质疏松症。这激发了临床影像对骨微结构的定量评估。 系统。然而，骨微结构的定量度量在OP和OA中仍未得到充分利用 这是因为目前骨科成像方式的空间分辨率有限。四肢的应用 CBCT在骨微结构定量成像中可能会对骨性关节炎和骨性关节炎产生很大影响，因为 (A)骨性关节炎主要发生在四肢，(B)在OP中，四肢远端的形态测量 被证明是骨折风险的指标，包括髋部骨折。再一次，空间分辨率 目前的四肢CBCT(≥0.25 mm)不足以完全分辨≤0.1 mm的小梁，限制了 在骨质量评估中的表现。我们打算通过 开发一种新型传感器，承诺提供必要的分辨率而不会影响 探测器灵敏度。这种探测器的有效性将通过CBCT扫描和 将结果与使用当前最先进的系统获得的结果进行比较。

Abstract Pathological changes in bone microarchitecture are associated with a broad range of musculoskeletal (MSK) diseases, including osteoporosis (OP) and osteoarthritis (OA). OP and OA carry significant healthcare burden, with an estimated 10 million US adults suffering from OP and 27 million afflicted by OA. This motivates quantitative assessment of bone microstructure on clinical imaging systems. Quantitative metrics of bone microarchitecture remain, however, underutilized in OP and OA because of limited spatial resolution of current orthopedic imaging modalities. Application of extremity CBCT in quantitative imaging of bone microstructure is likely to have high impact in OA and OP because (a) OA occurs primarily in the extremities, and (b) in OP, morphological measurements in distal extremities were shown to be indicative of fracture risk, including of hip fractures. Again, the spatial resolution of current extremity CBCT (≥0.25 mm) is insufficient to fully resolve the ≤0.1 mm trabeculae, limiting the performance in assessment of bone quality. We intend to address this specific issue through the development of a novel sensor that promises to provide the necessary resolution without compromising detector sensitivity. Efficacy of such a detector will be demonstrated through CBCT scanning and comparing results to those obtained using the current state-of-the-art system.