Clinical Pharmacology Shared Resource

临床药理学共享资源-项目总结 2012年成立为堪萨斯大学癌症中心（KUCC），开发共享资源， 临床药理学共享资源（CPSR）被选为2015年建立的共享资源， 由格雷戈里·里德博士领导这个共享资源有三个功能组件。 1.相关实验室（Correlative Laboratories），LaToya Berry导演。相关实验室提供符合GXP的 临床研究样本的采集、处理和储存或运输。在赞助商 协议或CPSR协议，工作人员有效和精确地从血液（全血， 血清、血浆或特定血细胞部分）、尿液和唾液或处理组织样品，然后 储存或转移这些样本进行分析。相关实验室位于患者附近 位于韦斯特伍德（堪萨斯大学）的KU临床研究中心（KU CRC）的治疗区 卫生系统的门诊临床设施）和堪萨斯大学卫生系统的主校区。 相关实验室还为社区肿瘤学站点提供科学和技术支持 和中西部癌症联盟（MCA）研究中心，以协助他们进行样本采集、处理和运输。 2.生物分析实验室-由Reed领导。位于KU CRC，这个符合GLP的设施准备 生物流体、细胞或组织样品，并分析它们的药物、药物代谢物 和其他小分子生物标志物。对两个UPLC串联四极杆质谱进行分析， 光谱仪，每年的总样品吞吐量超过30，000个样品。 3.药代动力学/药效学（PK/PD）单位-也由Reed指导。里德进行计算 使用Phoenix/WinNonlin®软件进行建模，以定义和解释药物及其代谢动力学。 行动 除了这些研究活动外，CPSR的工作人员还在教育未来方面发挥重要作用。 医生和研究人员，以及护士和研究协调员目前参与癌症临床 临床药理学的理论和实践，以及临床药理学的应用 药理学导致更强大的和翔实的结果，从临床试验。

Clinical Pharmacology Shared Resource – Project Summary Established as a University of Kansas Cancer Center (KUCC) developing shared resource in 2012 and selected as an established shared resource in 2015, the Clinical Pharmacology Shared Resource (CPSR) is led by Gregory Reed, PhD. This shared resource has three functional components. 1. Correlative Laboratories - directed by LaToya Berry. The Correlative Laboratories provide GXP-compliant acquisition, processing and storage or shipping of clinical research samples. Following either a sponsor's protocol or CPSR protocols, the staff efficiently and precisely prepares samples from blood (whole blood, serum, plasma or specific blood cell fractions), urine and saliva or processes tissue samples, and then stores or transfers those samples for analysis. The Correlative Laboratories are located near patient treatment areas at the KU Clinical Research Center (KU CRC), Westwood (The University of Kansas Health System's outpatient clinical facility) and at The University of Kansas Health System's main campus. The Correlative Laboratories also provide scientific and technical support to the community oncology sites and Midwest Cancer Alliance (MCA) sites to assist them in sample acquisition, processing and shipping. 2. Bioanalytical Laboratory - led by Reed. Located at the KU CRC, this GLP-compliant facility prepares biological fluids, cells or tissue samples, and analyzes them for concentrations of drugs, drug metabolites and other small molecule biomarkers. Analyses are performed on two UPLC-tandem quadrupole mass spectrometers, with a combined sample throughput of over 30,000 samples per year. 3. Pharmacokinetics/Pharmacodynamics (PK/PD) Unit – also directed by Reed. Reed performs calculations and modeling using the Phoenix/WinNonlin® software to define and interpret the kinetics of drugs and their actions. In addition to these study-specific activities, the staff of the CPSR also play a major role in educating future physicians and researchers, as well as nurses and study coordinators currently involved in cancer clinical trials, on the theory and practice of clinical pharmacology and on how those applications of clinical pharmacology result in more powerful and informative results from clinical trials.