Neurobehavioral_Evaluation-Core

核心F-神经行为评估核心 Gerard Gioia，博士 核心总监 儿科神经心理学科长 儿童国家卫生系统 麦迪逊·贝尔，博士，ABPP 人类神经行为评估核心主任 儿科神经心理学研究科主任 儿童国家卫生系统 泽娜·奎萨多，医学博士 动物神经行为评估中心主任 谢赫·扎耶德儿科外科创新研究所研究员 麻醉学和止痛科 儿童国家卫生系统 约书亚·科尔宾，博士 动物神经行为评估中心联席主任 神经科学研究中心副教授 儿童国家卫生系统 劳伦·肯沃西，博士 人类神经行为评估核心研究员 自闭症谱系障碍中心(CASD)主任 儿童国家卫生系统 李旺，医学博士，博士 经理/职员科学家，动物神经行为评估核心 谢赫·扎耶德儿科外科创新研究所 儿童国家卫生系统 摘要 该提案通过提供核心服务来响应RFA-HD-14-012， 治疗和改善智力和发育障碍(IDD)。NEC的主要目标是 利用标准和尖端的神经行为和认知方法来加深我们的理解 健康的和患病的大脑解剖、功能和病理生理学。为了实现这一目标， 对神经行为和认知结果的测量是研究非典型性和非典型性 典型发展。因此，NEC支持的研究的目的是关注发展， IDD动物模型和患有各种疾病的儿童的认知和行为结果 神经遗传性、神经发育或获得性神经疾病。此外，在技术上的进步 通过多层次的、翻译的、 从临床前(动物)研究进展到人类研究的方法。总体而言，NEC的目标是引导 调查人员使用神经行为/认知测试来帮助定义具体而复杂的 神经行为和神经心理过程。NEC的目标是：目标1：在 适合个别项目的水平，包括最大限度地提高测试和技术开发水平；目标2： 向刚果民主共和国--刚果民主共和国社区提供个人和团体教育和培训；目标3：促进 并促进跨项目的核心协作。NEC的重要性是采用以下措施 将神经疾病的潜在机制与行为和认知发展联系起来 结果。NEC为DC-IDDRC调查人员提供了一个强大的平台，以改善对国家- 先进的神经行为和认知工具，提高临床前和临床的整体质量 整个DC-IDDRC都在进行神经行为研究。此外，Core还改进了 通过提供访问专家人员和/或测试材料来最大限度地提高成本效益，从而提高效率。

CORE F - NEUROBEHAVIORAL EVALUATION CORE Gerard Gioia, PhD Core Director Chief, Division of Pediatric Neuropsychology Children's National Health System Madison Berl, PhD, ABPP Director, Human Neurobehavioral Evaluation Core Director of Research, Division of Pediatric Neuropsychology Children's National Health System Zena Quezado, MD Director , Animal Neurobehavioral Evaluation Core Investigator, Sheikh Zayed Institute for Pediatric Surgical Innovation Division of Anesthesiology and Pain Medicine Children's National Health System Joshua Corbin, PhD Co-Director, Animal Neurobehavioral Evaluation Core Associate Professor, Center for Neuroscience Research Children's National Health System Lauren Kenworthy, PhD Investigator, Human Neurobehavioral Evaluation Core Director, Center for Autism Spectrum Disorders (CASD) Children's National Health System Li Wang, MD, PhD Manager/Staff Scientist, Animal Neurobehavioral Evaluation Core Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Health System Abstract The proposal responds to RFA-HD-14-012 by providing core services that advance the diagnosis, prevention, treatment, and amelioration of intellectual and developmental disabilities (IDD). The primary aim of the NEC is to leverage standard and cutting edge neurobehavioral and cognitive approaches to further our understanding of healthy and diseased brain anatomy, function, and pathophysiology. In order to realize this goal, measurement of neurobehavioral and cognitive outcomes is a crucial endpoint for studies of both atypical and typical development. The aims of the studies supported by the NEC, therefore, focus on developmental, cognitive, and behavioral outcomes in animal models of IDD and in children who have a variety of neurogenetic, neurodevelopmental, or acquired neurological disorders. Furthermore, advancement in the diagnosis, prevention, treatment, and amelioration of IDD is maximized through a multi-level, translational, approach that progresses from preclinical (animal) to human studies. Overall, the goal of the NEC is to guide investigators to use neurobehavioral/cognitive testing to assist in defining specific, yet complex, neurobehavioral and neuropsychological processes. Aims of the NEC are to: AIM 1: Provide services at a level appropriate to individual projects including maximizing test and technology development; AIM 2: Provide individual and group education and training to the DC-IDDRC community; and AIM 3: Promote and facilitate Core collaboration across projects. The importance of the NEC is to employ measures that link the underlying mechanisms of neurological disorders with behavioral and cognitive developmental outcomes. The NEC affords DC-IDDRC investigators access to a robust platform to improve access to state- of-the-art neurobehavioral and cognitive tools and to enhance the overall quality of preclinical and clinical neurobehavioral research being conducted throughout the DC-IDDRC. In addition, the Core improves efficiency by providing access to expert personnel and/or testing materials that maximize cost effectiveness.