Scientific Core (ETR)

实施科学文献强调了将研究转向常规所面临的挑战 实践，并认识到建立文献基地的重要性，以促进循证证据的扩大 练习。在我们提议的U19中，我们的跨学科研究团队致力于研究HIV+ 青年和有感染风险的青年改善他们的健康和福祉，并通过以下方式发展IS领域 采用三种效力-实施混合设计，均涉及自我管理：1)a) 类型1设计(Belzer和Brown)，主要目的是确定临床治疗的有效性 干预，次要目的是更好地理解实施的背景；2)类型2设计 (Parsons)，其中的主要目标是确定临床干预的有效性和 实施战略的可行性和实用性；以及3)类型3设计(NAAR)，其中主要目标是 确定执行战略的效用，次要目标是评估以下方面的成效 与级联相关的结果。与我们推进实施科学的总体目标一致，我们的团队 建立了实施科学核心(ISC)，以最大限度地提高项目效率，并 采用实施概念模型Exploration-Preparation-Implementation-Sustainment(EPIS)，以 跨研究的地面实施规划、研究和测量。特别是，这项研究 项目将跨阶段检查EPIS的内部和外部环境因素-从探索提高适合度的方法 到可能影响积极执行的特征，如社会政治背景、领导力、 促进者对循证实践、财政可行性、可接受性和可行性的态度 干预措施。具体地说，ISC将：(1)促进和支持统一的实施科学方法 研究，特别是在艾滋病毒携带者或高危青年自我管理方面；(2)提供资源 就实施科学问题为新开发的ATN4中的早期职业生涯和其他研究人员提供支持 与他们的研究有关；和(3)更多地传播干预措施、支助材料和执行 与青少年艾滋病毒/艾滋病预防和治疗有关的研究结果。ISC的加入提供了一个 跨研究项目协同的机会，以系统地扩展实施科学 与青年艾滋病毒自我管理干预有关的研究，对实地和那些寻找的人的贡献 寻求扩大此类干预措施的途径。

The implementation science literature underscores the challenges associated with moving research to routine practice, and acknowledges the importance of building the literature base to facilitate scale-up of evidencebased practices. In our proposed U19, our interdisciplinary research team is committed to working with HIV+ youth and youth at risk of infection to improve their health and well-being and to develop the IS field by employing three types of effectiveness-implementation hybrid designs, all addressing self-management: 1) a Type 1 design (Belzer and Brown) in which the primary aim is to determine the effectiveness of clinical intervention with a secondary aim to better understand the context for implementation; 2) a Type 2 design (Parsons) in which the primary aims are to determine both the effectiveness of the clinical intervention and the feasibility and utility of an implementation strategy; and 3) a Type 3 design (Naar), in which the primary aim is to determine the utility of an implementation strategy with a secondary aim on assessing effectiveness on cascade-related outcomes. Consistent with our overall goal of advancing implementation science, our team has established an Implementation Science Core (ISC) to maximize efficiencies across projects and has adopted an implementation conceptual model, Exploration-Preparation-Implementation-Sustainment (EPIS), to ground implementation planning, research, and measurement across the studies. In particular, the Research Projects will examine EPIS inner and outer context factors across phases—from exploring ways to improve fit to characteristics that may influence active implementation, such as the sociopolitical context, leadership, facilitator attitudes toward evidence-based practices, fiscal viability, and acceptability and feasibility of interventions. Specifically, the ISC will: (1) facilitate and support a unified approach to implementation science research particularly as it applies to self-management by HIV+ or at risk youth; (2) provide resources to support early career and other investigators in the newly developed ATN4 with implementation science issues related to their studies; and (3) increase dissemination of interventions, support materials, and implementation study findings relevant to adolescent HIV/AIDS prevention and treatment. The inclusion of the ISC provides an opportunity for synergy across Research Projects to systematically expand the implementation science research related to youth HIV self-management interventions, a contribution to field and to those looking towards avenues of scaling up such interventions.