Precision Medicine: Moving Theory into Practice

摘要 这一研究开发研讨会将为监管机构、 经济、支付者、临床和科学社区讨论个性化和 精准医学(PPM)及其在卫生保健系统中实施的相关挑战。作为一种 范例，我们将把上述观点应用于自身免疫和炎症性疾病，这是一种快速演变的疾病 PPM中的专业，以努力将PPM扩展到肿瘤学和其他专业之外 已申请。研讨会将有以下四个目标：1)我们将审查PPM方法，重点是 关于那些用于自身免疫和炎症性疾病的护理，从广泛的角度来考察 它们的实用性和局限性。目标将是确定哪些方法(如果有的话)最有可能满足 PPM在卫生保健系统中实施时的理论承诺。2)与关键医疗保健部门的投入 系统利益相关者，我们将探讨与实施 Ppm方法进入医疗保健系统。然后我们将提出一项行动计划，以指导实施 最有希望的PPM方法应用于临床护理。3)我们将制定研究议程，以确定优先事项 未来的研究。本议程将总结研讨会的结论，并为今后的研究提供框架。 对这些发现进行扩展，以更好地了解PPM方法的效用和局限性，并加快 将PPM的开发和实施转化为标准的临床护理。4)我们将培养一名青年调查员 该计划旨在激励不同的学生和年轻研究人员在PPM研究领域追求职业生涯。 我们的计划将允许青年和青少年之间建立协作网络并交流知识和思想 成熟的研究人员，目标是鼓励年轻的研究人员从事相关的研究职业 提交给PPM，并最终向AHRQ征集提交赠款提案，并为科学文献做出贡献。 总体而言，这次研讨会将为未来的研究提供重要的新见解和框架，以推动 了解PPM并加快将PPM开发和实施到标准临床护理中， 以及探讨在医疗保健系统中实施PPM方法的挑战和战略 克服这些挑战。

ABSTRACT This research development workshop will provide a collaborative environment for members of the regulatory, economic, payer, clinical, and scientific communities to discuss the utility and limitations of personalized and precision medicine (PPM) and challenges associated with its implementation into health care systems. As an exemplar, we will apply the above perspectives to autoimmune and inflammatory diseases, a rapidly evolving specialty within PPM, in effort to extend PPM beyond oncology and other specialties to which is it commonly applied. The workshop will have the following four aims: 1) We will examine PPM approaches, with an emphasis on those used in autoimmune and inflammatory disease care, from a broad range of perspectives to examine their utility and limitations. The goal will be to determine which approaches—if any—are most likely to fulfill the theoretical promises of PPM when implemented into health care systems. 2) With input from key health care systems stakeholders, we will explore possible considerations and challenges associated with implementing PPM approaches into health care systems. We will then propose an action plan to guide the implementation of the most promising PPM approaches into clinical care. 3) We will develop a research agenda to set priorities for future studies. This agenda will summarize the workshop conclusions and provide a framework for future studies to expand on these findings to better understand the utility and limitations of PPM approaches and accelerate the development and implementation of PPM into standard clinical care. 4) We will develop a Young Investigator Program to motivate a diverse group of students and young investigators to pursue careers in PPM research. Our Program will allow for collaborative networking and exchange of knowledge and ideas among young and established investigators, with the goal of encouraging young investigators to pursue research careers related to PPM, and ultimately submit grant proposal to AHRQ solicitations and contribute to the scientific literature. Overall, this workshop will provide critical new insights and a framework for future research to advance the understanding of PPM and accelerate the development and implementation of PPM into standard clinical care, as well as explore the challenges of implementing PPM approaches into health care systems and strategies for overcoming these challenges.