University of Kansas Alzheimer's Disease Core Centers

项目概要：总体 堪萨斯大学阿尔茨海默病中心（KU ADC）促进了对阿尔茨海默病的研究 疾病（AD）、与AD相关的脑病症和脑老化。我们提供支持、服务、数据集， 生物标本提供给机构、区域、国家和国际研究者。 KU ADC改变了我们家机构的AD相关研究，是 KU神经科学景观。我们受益于并加强了一个机构T32计划，收到定期 从一个机构神经科学家培训基金的支持，与KU部门密切合作，神经科学家 教师招聘，是KU神经病学发现研究所（KU IND）的关键组成部分。我们 进一步保持与其他KU实体的互动合作，包括KU Landon老龄化中心 （LCOA），临床转化科学奖（CTSA）中心，NeuroNext网站和KU癌症中心。我们 创建与AD相关的临床和教育基础设施，使我们成为一个重要的社区和区域集件。 虽然KU ADC促进了AD研究的阵列，一个突出的中心目标是支持，促进， 并推进研究，解决衰老过程中能量代谢改变的原因和后果， AD.能量代谢（即生物能量学）的变化与脑老化和AD有关。关于ADC 开发了一个独特的基础设施，使创新研究有关的基础，转化， 临床能量代谢相关问题。我们处于独特的位置去探索改变的能量 能量代谢与脑老化和AD的关系，并测试能量代谢的治疗潜力 治疗AD的方法。我们目前支持正在测试的最先进的程序， 体育锻炼和饮食干预对大脑健康的影响，开发药理学方法， 操纵大脑能量代谢，探索线粒体基因对AD的贡献，并验证 线粒体和其他能量代谢相关的生物标志物。通过推进我们对能源的理解 代谢在AD中的作用在多个层面，开发新的能力，并测试创新的方法 为了测量、表征和治疗AD能量代谢功能障碍，我们讨论了一种严重的AD 知识差距，并定位我们自己，以潜在地改变目前的AD研究和临床实践模式。 我们的第一个融资周期（2011- 2016年）专注于中心基础设施，我们的第二个融资周期将延长 我们的联邦资助的调查项目组合，以进一步补充一流的，创新的研究 我们目前支持的项目通过这些努力和我们提供的研究基础设施，我们将 继续我们的使命，开发预防和治疗AD的干预措施。我们将实现这些目标 通过以下具体目标：（1）推进AD和脑老化研究;（2）作为中西部中心 用于AD研究、临床护理和教育;以及（3）加强ADC网络。

PROJECT SUMMARY: OVERALL The University of Kansas Alzheimer's Disease Center (KU ADC) promotes research into Alzheimer's disease (AD), brain disorders relevant to AD, and brain aging. We provide support, services, datasets, and biospecimens to institutional, regional, national, and international investigators. The KU ADC transforms AD-relevant research at our home institution and is an indispensable part of the KU neuroscience landscape. We benefit from and enhance an institutional T32 program, receive regular support from an institutional neuroscientist training fund, work closely with KU departments on neuroscientist faculty recruitment, and are a key component of the KU Institute for Neurologic Discoveries (KU IND). We further maintain interactive collaborations with other KU entities including the KU Landon Center on Aging (LCOA), Clinical Translational Science Award (CTSA) Center, NeuroNext site, and KU Cancer Center. We create AD-related clinical and educational infrastructure, making us a vital community and regional set-piece. While the KU ADC promotes an array of AD research, a prominent Center objective is to support, promote, and advance studies that address the causes and consequences of altered energy metabolism in aging and AD. Changes in energy metabolism (i.e, bioenergetics) have been linked to brain aging and AD. The KU ADC has developed a unique infrastructure that enables innovative research pertinent to basic, translational, and clinical energy metabolism-relevant questions. We are uniquely positioned to explore how altered energy metabolism contributes to brain aging and AD, and test the therapeutic potential of energy metabolism manipulations for the treatment of AD. We currently support state of the art programs that are testing the effects of physical exercise and dietary interventions on brain health, developing pharmacologic approaches to manipulate brain energy metabolism, exploring the contribution of mitochondrial genes to AD, and validating mitochondrial and other energy metabolism-related biomarkers. By advancing our understanding of energy metabolism's role in AD at multiple levels, developing novel capabilities, and testing innovative approaches intended to measure, characterize, and treat AD energy metabolism dysfunction we address a critical AD knowledge gap and position ourselves to potentially shift current AD research and clinical practice paradigms. Our first funding cycle (2011-16) focused on Center infrastructure, and our second funding cycle will extend our portfolio of federally funded investigator projects to further complement the first class, innovative research programs we currently support. Through these efforts and the research infrastructure we provide, we will pursue our mission to develop interventions that can prevent and treat AD. We will accomplish these goals through the following Specific Aims: (1) Advance AD and brain aging research; (2) Serve as a Midwestern hub for AD research, clinical care, and education; and (3) Enhance the ADC network.