The Health ePeople Resource for Mobilized Research

资源核心--项目摘要/摘要 我们寻求创建Health ePeople资源，这是一个灵活、易于访问和可靠的基础设施，以 开展移动健康研究。这项工作将建立在目前的健康电子心脏研究基础上，这是一项基于互联网的临床研究 这个研究平台已经招募了来自世界各地的20,000多名参与者。虽然 最初开发用于研究心血管疾病的Health eHeart被来自多个领域的研究人员使用， 并帮助我们启动当前RFA中规定的许多目标。我们已经成功地实施了 构建了用户友好的界面，用于收集患者报告的结果、经过验证的调查数据以及与 多个传感器、设备和应用程序；我们拥有IRB批准的系统，使用模块化电子同意； 我们有超过20,000名深度参与的参与者有兴趣为移动健康研究做出贡献；我们有 制定方法，使外部调查人员能够以可定制的方式利用和招募他们自己的参与者； 我们开发了一个研究管理门户(包括实时仪表板和参与者特征- 基于过滤系统)和可供外部调查人员使用的灵活消息传递系统；我们有 建立了一个数据库和数据管理系统，旨在坚持最高标准的隐私， 安全性和可靠性；我们对该平台进行了迭代和调整，以利用新兴的 技术和尖端方法。在这些优势的基础上，我们准备充分利用 该奖项提供的机会，将Health eHeart研究转变为一般Health ePeople 资源。资源核心将负责以下目标：扩展、改进和迭代 我们面向参与者的门户旨在远程收集自我报告、医疗记录、设备、传感器 和移动数据；扩展和改进冗余、可扩展和容错的后端和数据库，以 可靠地管理大量结构化和非结构化数据；扩展、改进、迭代和维护 易于访问的界面，使各种研究人员能够快速实施研究以进行定制 并利用参与者门户、后端和数据库进行mHealth研究；以扩展、改进和 迭代用于数据分析、数据可视化和与外部数据库的互操作性的基础设施； 扩大和维护参与mHealth的研究参与者队列，该研究参与者旨在提供快速 可定制的观察性研究、验证性研究和随机干预试验的选择； 最后，开发和部署一个在财务和技术上支持Health ePeople的模式 在拟议的供资期间以外的资源。

RESOURCE CORE— PROJECT SUMMARY/ABSTRACT We seek to create the Health ePeople Resource, a nimble, readily-accessible, and reliable infrastructure to conduct mHealth research. This effort will build on the current Health eHeart Study, an internet-based clinical research platform that has enrolled more than 20,000 engaged participants from around the world. Although initially developed to study cardiovascular disease, Health eHeart is in use by investigators from multiple fields, and helps us jumpstart many of the objectives set out in the current RFA. We have successfully implemented a user-friendly interface built to collect patient-reported outcomes, validated survey data, and integrations with multiple sensors, devices, and apps; we have an IRB approved system using modular electronic consenting; we have over 20,000 deeply involved participants interested in contributing to mHealth research; we have developed ways for external investigators to utilize and enroll their own participants in a customizable fashion; we have developed a study management portal (including a real-time dashboard and participant characteristic- based filtering system) and a flexible messaging system that can be utilized by external investigators; we have built a database and data management system constructed to adhere to the highest standards of privacy, security, and reliability; and we have iterated and adapted the platform to take advantage of emerging technology and cutting-edge methods. Building from these strengths, we are ready to fully leverage the opportunities afforded by this award, transforming the Health eHeart Study into a general Health ePeople Resource. The Resource Core will be responsible for the following objectives: to expand, improve and iterate upon our participant-facing portal designed to remotely collect self-reported, medical record, device, sensor and mobile data; to expand and improve a redundant, scalable, and fault-tolerant backend and database to reliably curate large quantities of structured and unstructured data; to expand, improve, iterate and maintain a readily accessible interface that enables rapid study implementation for a variety of investigators to customize and utilize a participant portal and backend and database for their mHealth research; to expand, improve and iterate an infrastructure for data analytics, data visualization, and interoperability with external databases; to expand and maintain a cohort of research participants engaged in mHealth that is constructed to provide rapid and customizable selection for observational studies, validation studies, and randomized interventional trials; and finally, to develop and deploy a model to financially and technologically sustain the Health ePeople Resource beyond the proposed funding period.