Opportunities Fund Management Core

机会基金管理核心（OFMC）的总体目标是促进早期阶段 支持创新或转化项目，特别是那些有可能导致实际应用的项目 辐射生物剂量学和预测及预防急性和迟发性损伤领域的产品。的 OFMC将支持1）试点项目（基础和转化研究）和2）导致 研究性新药（IND）-使能研究和医学对策（MCM）开发。 OFMC将为堆芯的运行制定SOP（标准操作程序）， 指导委员会的批准，将成为其运作的模板。 该过程的核心是向OFMC提供最佳的应用程序集，OFMC将使用 独特的两阶段导师评审计划;第一阶段是强制性的投标前意向书 潜在的申请人。这使OFMC能够将申请人与合适的CMCRC科学家配对， 创造指导/建议机会，从而形成与CMCRC协调一致的更强有力的完整提案 问题和目标。第二阶段是在六周后提交完整的提案。OFMC 将协调征求意向书和随后的建议书的过程，以及协调 审查提案，并最终向CMCRC指导委员会提供一套审查分数。 创新和转化研究，以及新的或早期阶段的研究人员，将得到大力强调 在审查过程中。 OFMC还将负责协调财务、IRB和 IACUC对次级接受机构的要求，以及财务监督和报告。OFMC将 协调年度进展报告，并在此基础上提出资金更新建议， 指导委员会。 重要的是，OFMC将为试点项目接受者提供介绍机会。所有试点 得奖者将被要求为年度CMCRC会议准备海报。与转向 委员会的批准，并根据这些海报，OFMC，与CCC合作，将提出和 在CMCRC年会上为试点获奖者组织一次海报小型演示会。

The broad objective of the Opportunities Fund Management Core (OFMC) will be to facilitate early stage support for innovative or translational projects, particularly those which have the potential to lead to practical products in the fields of radiation biodosimetry and prediction and prevention of acute and delayed injuries. The OFMC will support 1) Pilot projects (basic and translational research) and 2) proposals that lead to Investigational New Drug (IND)-enabling studies and Medical Countermeasure (MCM) development. The OFMC will generate an SOP (Standard Operating Procedure) for the operation of the Core which, after Steering Committee approval, will be the template for its operation. Central to the process is getting the best possible set of applications to the OFMC, and the OFMC will use a unique two-phase mentor-based review program; The first phase is a mandatory pre-proposal Letter of Intent from potential applicants. This enables the OFMC to pair applicants with appropriate CMCRC scientists to create mentoring/advising opportunities that lead to stronger full proposals that are in tune with CMCRC issues and goals. The second phase, due six weeks later, is the submission of the full proposal. The OFMC will coordinate the process of soliciting Letters of Intent and subsequent Proposals, as well as coordinating the review of the proposals, and finally providing a set of review scores to the CMCRC Steering Committee. Innovative and translational research, as well as New or Early Stage Investigators, will be strongly emphasized in the review process. The OFMC will also be responsible for coordinating all necessary documentation of financial, IRB, and IACUC requirements with subrecipient institutions, as well as financial oversight and reporting. The OFMC will also coordinate annual progress reports, and based on these, will make funding renewal recommendations to the Steering Committee. Importantly, the OFMC will facilitate presentation opportunities for the pilot project recipients. All pilot awardees will be requested to prepare a poster for the annual CMCRC meeting. With the Steering Committee's approval, and based on these posters, the OFMC, in collaboration with the CCC, will propose and organize a poster mini-presentation session for pilot awardees at the CMCRC Annual Meeting.