Molecular Analysis of Disease Pathways

摘要/摘要 该提案要求继续支持生物医学研究卓越中心的发展 疾病路径分子分析中心(CMADP)，成立于2012年。科学的主题是 CMADP是创建和实施使能技术，以研究基因， 疾病的生化和物理根源。该中心是由拉尔夫·N·亚当斯组织和指导的 堪萨斯大学(KU)生物分析化学研究所。该中心利用当前的 KU在生物分析化学、分子设计、基因组学和生物工程领域的优势。三 核心实验室是在第一阶段建立的，重点是为初级调查人员提供工具 开发或应用新的使能技术来研究疾病途径。这些是基因组 测序核心、合成化学生物学核心(以前的分子探针核心)和 微细加工和微流体芯。 这三个核心促进了堪萨斯州的生物医学研究 初级和高级调查人员和吸引参与生物医学研究的教员到堪萨斯州董事会 执政官机构。我们对第二阶段的愿景是继续发展一个鼓励基础研究的中心 科学家开发可用于促进与健康相关的研究的使能技术。这将是 通过继续构建强大的研究基础设施来增强教职员工的能力 研究人员独立竞争个人NIH R01和类似的研究资助。我们的长期合作 目标仍然是实现一大批成功的、多学科的、独立但合作的 研究人员，以及我们的核心实验室未来成为自给自足的企业。

SUMMARY/ABSTRACT This proposal requests support to continue the development of the Center for Biomedical Research Excellence for Molecular Analysis of Disease Pathways (CMADP), which was established in 2012. The scientific theme of the CMADP is the creation and implementation of enabling technologies for the investigation of the genetic, biochemical and physical origins of disease. The Center is organized and directed out of the Ralph N. Adams Institute for Bioanalytical Chemistry at the University of Kansas (KU). The Center capitalizes on the current strengths of KU in the fields of bioanalytical chemistry, molecular design, genomics and bioengineering. Three core labs were established during Phase I focused on providing tools for junior investigators working on the development or application of new enabling technologies to study disease pathways. These are the Genome Sequencing Core, the Synthetic Chemical Biology Core (formerly the Molecular Probes Core) and the Microfabrication and Microfluidics Core. The three cores have catalyzed biomedical research in the State of Kansas by enhancing the research of junior and senior investigators and attracting faculty involved in biomedical research to Kansas Board of Regents institutions. Our vision for Phase II is to continue to develop a center that encourages basic research scientists to develop enabling technologies that can be used to foster health related research. This will be accomplished by continuing to build a powerful research infrastructure that enhances the ability of faculty investigators to compete independently for individual NIH R01 and comparable research grants. Our long-term goal continues to be to attain a critical mass of successful, multidisciplinary, independent but collaborative investigators, and for our Core laboratories to become self-sustaining enterprises in the future.