Molecular Analysis of Disease Pathways

总结/摘要 该提案要求支持继续发展生物医学研究卓越中心 疾病途径分子分析（CMADP），成立于2012年。的科学主题 CMADP是创造和实施使能技术，用于研究遗传， 疾病的生物化学和物理起源。该中心是组织和指导的拉尔夫N。亚当斯 堪萨斯大学（KU）生物分析化学研究所。该中心利用目前 KU在生物分析化学、分子设计、基因组学和生物工程领域的优势。三 在第一阶段建立了核心实验室，重点是为初级研究人员提供工具， 开发或应用新的使能技术来研究疾病途径。这些是基因组 测序核心，合成化学生物学核心（以前的分子探针核心）和 微加工和微流体核心。 这三个核心通过加强以下方面的研究，促进了堪萨斯州的生物医学研究： 初级和高级研究人员和吸引教师参与生物医学研究的堪萨斯董事会 执法机构。我们对第二阶段的愿景是继续发展一个鼓励基础研究的中心 科学家开发可用于促进健康相关研究的技术。这将是 通过继续建立强大的研究基础设施，提高教师的能力， 研究人员独立竞争个人NIH R 01和可比的研究赠款。我们的长期 我们的目标仍然是实现一个成功的，多学科的，独立的，但协作的临界质量 研究人员，并为我们的核心实验室成为自我维持的企业在未来。

SUMMARY/ABSTRACT This proposal requests support to continue the development of the Center for Biomedical Research Excellence for Molecular Analysis of Disease Pathways (CMADP), which was established in 2012. The scientific theme of the CMADP is the creation and implementation of enabling technologies for the investigation of the genetic, biochemical and physical origins of disease. The Center is organized and directed out of the Ralph N. Adams Institute for Bioanalytical Chemistry at the University of Kansas (KU). The Center capitalizes on the current strengths of KU in the fields of bioanalytical chemistry, molecular design, genomics and bioengineering. Three core labs were established during Phase I focused on providing tools for junior investigators working on the development or application of new enabling technologies to study disease pathways. These are the Genome Sequencing Core, the Synthetic Chemical Biology Core (formerly the Molecular Probes Core) and the Microfabrication and Microfluidics Core. The three cores have catalyzed biomedical research in the State of Kansas by enhancing the research of junior and senior investigators and attracting faculty involved in biomedical research to Kansas Board of Regents institutions. Our vision for Phase II is to continue to develop a center that encourages basic research scientists to develop enabling technologies that can be used to foster health related research. This will be accomplished by continuing to build a powerful research infrastructure that enhances the ability of faculty investigators to compete independently for individual NIH R01 and comparable research grants. Our long-term goal continues to be to attain a critical mass of successful, multidisciplinary, independent but collaborative investigators, and for our Core laboratories to become self-sustaining enterprises in the future.