Translational and Precision Medicine Resources Core (TRAP)

陷阱芯摘要 翻译和精确医学资源核心(TRAP)核心的开发是为了加快 将基础科学/实验室研究的成果转化为新疗法，方法是提供 为研究人员提供进入翻译和临床领域所需的服务。此外， 提供的服务将使非皮肤科医生能够适当地解决以下具体问题 可能与原发皮肤病的研究相关的皮肤病，或 其他器官系统有皮肤表现，或对治疗有皮肤反应。精密医学是 与最先进的研究和医疗保健的持续进步密不可分。陷阱将提供 协助研究人员发现、评估和验证生物标记物的前沿方法。我们会 提供复杂的计算分析、生物信息学和数据管理，以推动 新的生物标记物进入临床使用领域，用于基于个人/个性化的风险评估、监测 进展或疾病，或预测治疗反应。这个陷阱将在替补和替补之间架起一座桥梁 诊所有四项战略服务，每项服务都旨在解决翻译的特定障碍。第一，陷阱 将在开发临床前和临床研究方面提供研究设计和生物统计学专业知识。 接下来，陷阱将提供皮肤组织和毛囊的确定和采购服务。 样品，这是我们机构一直很需要的一种关键资源，我们预计将广泛 由资源社区成员使用。我们将提供全国斑秃登记处的链接 数据库，从而允许访问已同意重新联系的数千人 进行更多的AA研究。此外，我们将提供专家咨询，以鉴定基因组和 有能力预测或量化治疗反应的分子生物标志物，以及 生物信息学和统计指南，以从从以下来源生成的原始数据中收集有用的生物学见解 先进的基因组和分子工具。

TRAP CORE ABSTRACT The Translational and Precision Medicine Resources Core (TRAP) core was developed to expedite the translation of findings derived from basic science/bench research into novel therapies, by providing investigators with the services needed to advance into the translational and clinical realm. In addition, the services provided will allow non-dermatologist physicians to appropriately address concerns specific to cutaneous diseases that may be relevant to research in both primary cutaneous disorders, or disorders of other organ systems with cutaneous manifestations, or cutaneous reactions to therapies.Precision medicine is inextricably linked to the continued advance of state of the art research and medical care. The TRAP will offer cutting edge approaches to assist investigators in biomarker discovery, assessment and validation. We will provide sophisticated computational analysis, bioinformatics and data management to drive the movement of novel biomarkers into the realm of clinical use for individual based/personalized risk assessment, monitoring of progression or disease, or predicting response to treatment. The TRAP will bridge the gap between bench and clinic with four strategic Services, each designed to address a particular barrier to translation. First, the TRAP will provide study design and biostatistical expertise in the development of pre-clinical and clinical studies. Next, the TRAP will offer services for the ascertainment and procurement of cutaneous tissue and hair follicle samples, a critical resource that has been in high demand at our institution, and we expect will be extensively utilized by resource community members. We will provide links to the National Alopecia Areata Registry Database, thereby allowing access to several thousand individuals who have given consent to be re-contacted for additional research in AA. Further, we will provide expert consultations in identifying genomic and molecular biomarkers that have the capability to predict or quantify treatment responses, as well as the bioinformatic and statistical guidance to glean useful biological insights from raw data generated from advanced genomic and molecular tools.