Waxholm Space for Rodent Neuroinformatics

摘要 神经科学中各种类型的数据收集现在比比皆是，而且还在继续增长，但它们缺乏访问权-- 能力，特别是以综合的方式，对普通调查员来说是一个持久而令人烦恼的挑战 并最终限制了这些资源的潜在影响。为了解决这一不良状态， 科学，国际神经信息学协调机构(INCF，http://incf.org/))在- 激光计划，以制定基于地图集的数据共享的标准和实践，并将其实例化，用于 最初，在基础设施、系统和方法中，啮齿动物的大脑能够服务于社区的科学目标- 坚持不懈。一个核心成果是瓦克斯霍尔姆空间(WHS)的开发和原型实现， 成年C57BL/6小鼠脑的标准坐标系及其基础数字图谱基础设施 (DAI)，允许研究人员查询在世界卫生组织注册为地图集中心的任何数据资源。就像它的反面一样- 在人脑研究中，Talairach坐标系的一个基本要求是标准化的能力 将用户数据转换为标准化空间；反向转换允许在用户的 原生空间。 该项目汇集了宾夕法尼亚大学和杜克大学在脑图谱方面的领先专业知识，以开发、评估和部署 社区支持下的这一关键功能将使基于WHS的啮齿动物协调成为可能 大脑研究，这将允许访问来自多个来源的数据、工具和分析。为此，一个 将为鼠标开发定义WHS规范坐标系的改进的多通道地图集 和RAT，扩大了可能的实验研究范围和可能应用的分析类型 到田野里的这些。这种首创的分析功能将通过一套工具来实现，这些工具可以支持 各种用户背景和需求。这些发展将通过它们在实际中的应用来评估 世界用例及其与主要社区资源的实际整合。圆满完成 该项目将充分实现Waxholm空间在啮齿动物神经科学研究中的价值，并导致立即 对这一领域产生了广泛的影响。

Summary Data collections of every variety now abound and continue to grow in the neurosciences but their lack of acces- sibility, especially in an integrative way, to the average investigator presents a persistent and vexing challenge to the field and ultimately limits the potential impact of these resources. To address this undesirable state of the science, the International Neuroinformatics Coordinating Facility (INCF, http://incf.org/) established the Digital At- lasing Program to formulate standards and practices for atlas-based data sharing, and to instantiate these, for the rodent brain initially, in infrastructure, systems and methods capable of serving the scientific goals of the commu- nity. A central outcome has been the development and prototypical implementation of Waxholm Space (WHS), a standard coordinate system for the adult C57BL/6 mouse brain, and its underlying digital atlasing infrastructure (DAI) that allows researchers to query any data resource registered to WHS as an atlas hub. As with its counter- part in human brain studies, the Talairach coordinate system, an essential requirement is the ability to normalize user data into standardized space; the inverse transformation allows standardized data to be accessed in user’s native space. This project brings together leading expertise in brain atlasing at Penn and Duke to develop, evaluate and deploy this critical functionality under community support that would make possible the WHS-based coordination of rodent brain research, which would allow access to data, tools, and analyses from multiple sources. Toward this end, an improved multi-modality atlas defining the canonical coordinate system of WHS will be developed for the mouse and rat, expanding both the range of experimental studies possible and the types of analyses that may be applied to these in the field. This first-of-its-kind analytic capability will be enabled by a suite of tools that accommodate a variety of user backgrounds and needs. These developments will be evaluated through their application to real- world use cases and their practical integration with major community resources. The successful completion of this project will fully realize the value of Waxholm Space in rodent neuroscience research and lead to immediate and broad impact on the field.