Nanoparticle-driven systems for tunable local pain relief

摘要 用于延长或触发局部麻醉的药物输送系统的研究 包括测量药物在体外和体内的液体释放。在这两种情况下，但是 特别是在体内，这些药物的浓度可能非常低--太低了 通过层析手段检测的。同样，在这两种情况下，可能都存在感兴趣的药物 与其他可能混淆药物检测和定量的化合物。这 这一问题通常用液-质联用(LC-MS)来解决。立法会- MS还有助于实时监测化学反应，以确定我们是否获得了 用于缓释和/或触发释放系统的所需产品，并优化化学品 合成路线。LC-MS是我们在我们的研究中经常使用的一种技术，该研究由 NIGMS。获得LC-MS一直是我们研究的一个严重瓶颈，因为只有一个 在我们的机构，它被严重超额认购。使用其他机构的LC-MS是昂贵的，时间- 耗费(旅行)，样品稳定性不佳，实时反应不切实际 监控。因此，我们正在申请行政补充以购买LC-MS 为了我们的实验室。

Summary The study of drug delivery systems for prolonged or triggerable local anesthesia invariably involves measuring the release of drugs into fluids, in vitro and in vivo. In both cases, but particularly in vivo, the drugs may be present at very low concentrations – too low to be detected by chromatographic means. Also in both cases, the drugs of interest may be present with other compounds that can confound the detection and quantitation of the drug. This problem is commonly overcome with liquid chromatography-mass spectrometry (LC-MS). LC- MS is also useful for chemical reaction monitoring in real time to determine whether we obtain the desired product for sustained and/or triggered release systems and to optimize the chemical synthesis routes. LC-MS is a technique that we have frequently used in our research funded by NIGMS. Access to LC-MS has been a serious bottleneck to our research since there is only one at our institution and it is heavily oversubscribed. Using other institutions' LC-MS is costly, time- consuming (travel), suboptimal for sample stability, and impractical for real time reaction monitoring. We are therefore applying for an administrative supplement to purchase an LC-MS for our lab.