SENSORS FOR DETECTION OF EXCESSIVE ALCOHOL CONSUMPTION

用于检测过量饮酒的传感器

• 批准号: 2046066
• 负责人: PAUL D HALE
• 金额: $ 25.73万
• 依托单位: BIO-TEK INSTRUMENTS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2046066
• 关键词: alanine transaminase; alcoholism /alcohol abuse; aspartate transaminase; biomarker; biomedical equipment development; biosensor device; crosslink; glutamyltransferase; immobilized enzymes; immunologic assay /test; microelectrodes; polymers

DESCRIPTION: (Adapted from the applicant's abstract) This project involves the development of biosensor based detection methods for the determination of several important markers of excessive alcohol consumption: alanine aminotransferase (ALT), aspartate aminotransferase (AST), y-glutamyltransferase (GGT), and carbohydrate deficient transferrin (CDT). Novel sensor design permits efficient operation where interferences due to dissolved oxygen and other spurious current measurements due to common interferents (e.g., ascorbate, urate) are minimized. During the Phase II program, this sensor technology will be optimized in order to provide rapid measurements requiring only small sample volumes. These optimized sensors will be extremely useful to researchers in fields related to alcoholism and alcohol abuse, and could serve an important role in the daily clinical practice of differential diagnostics of alcohol-related organ damage and in follow-up studies of alcoholism treatment programs.

描述：（改编自申请人的摘要）该项目 涉及开发基于生物传感器的检测方法 酒精过量的几个重要标志物的测定 消耗：丙氨酸转氨酶（ALT）、天冬氨酸转氨酶 (AST)、γ-谷氨酰转移酶 (GGT) 和碳水化合物缺乏 转铁蛋白（CDT）。新颖的传感器设计可实现高效运行 溶解氧和其他杂散电流造成的干扰 由于常见干扰物（例如抗坏血酸、尿酸盐）导致的测量结果 最小化。在第二阶段计划中，该传感器技术将 优化以提供快速测量，只需要很小的 样本量。这些优化的传感器对于 酗酒和酒精滥用相关领域的研究人员，并且可以 在鉴别诊断的日常临床实践中发挥着重要作用 酒精相关器官损伤的诊断和后续研究 酗酒治疗计划。