SENSORS FOR DETECTION OF EXCESSIVE ALCOHOL CONSUMPTION

描述：（改编自申请人摘要）本项目 涉及基于生物传感器的检测方法的发展， 测定过量酒精的几个重要指标 消耗：丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶 (AST)、γ-谷氨酰转移酶（GGT）和碳水化合物缺乏 转铁蛋白（CDT）。新颖的传感器设计可实现高效运行， 溶解氧和其他寄生电流引起的干扰 由于共同干扰物的测量（例如，抗坏血酸盐、尿酸盐）是 最小化在第二阶段计划中，这种传感器技术将被 优化，以便提供快速测量， 样品体积。这些优化的传感器将非常有用， 酒精中毒和酒精滥用相关领域的研究人员， 在日常临床实践中发挥重要作用， 酒精相关器官损伤的诊断和 酒精中毒治疗项目

DESCRIPTION: (Adapted from the applicant's abstract) This project involves the development of biosensor based detection methods for the determination of several important markers of excessive alcohol consumption: alanine aminotransferase (ALT), aspartate aminotransferase (AST), y-glutamyltransferase (GGT), and carbohydrate deficient transferrin (CDT). Novel sensor design permits efficient operation where interferences due to dissolved oxygen and other spurious current measurements due to common interferents (e.g., ascorbate, urate) are minimized. During the Phase II program, this sensor technology will be optimized in order to provide rapid measurements requiring only small sample volumes. These optimized sensors will be extremely useful to researchers in fields related to alcoholism and alcohol abuse, and could serve an important role in the daily clinical practice of differential diagnostics of alcohol-related organ damage and in follow-up studies of alcoholism treatment programs.