Assessing impact of drinking water exposure to GenX (hexafluoropropylene oxide dimer acid) in the Cape Fear River Basin, North Carolina

Genx(2，3，3，3-tetrafluoro-2-(heptafluoropropoxy)-propanoate)是一种短链全氟烷基 在不粘涂料生产过程中产生的物质(PFAS)。这种化学物质已被检测到 在北卡罗来纳州的恐惧角河里。开普省的恐惧河是 开普省下游恐惧河流域的约30万居民，包括新汉诺威的居民， 布伦瑞克和彭德县。2017年6月，社区关注饮酒中的这种化学物质 水导致市民举行多次公开集会，试图获取有关他们的信息 与饮用饮用水相关的潜在接触和由此产生的健康影响。AS 由于社区的关注，据报道，这家化工厂已经停止向 河。然而，在成品饮用水中仍然可以检测到它，社区关注的问题仍然存在。 是存在的。该项目旨在帮助解决有关GenX接触和健康的社区问题 效果。关于GenX是如何储存在体内的，GenX的毒性，以及GenX在体内存储了多久，人们知之甚少 这种化学物质将留在环境中。针对这些问题，我们计划开展一项 受公共事业服务的开普福里河下游居民的社区研究 水。我们将与恐惧角河流守望者和新汉诺威县的社区合作伙伴合作 卫生署协助确定有代表性的居民样本，以收集生物 样本，并让社区了解有关GenX的已知情况和研究内容 发现。我们计划招募约400名威尔明顿地区居民(100名男性，100名女性，100名男孩，100名女孩) 提供血液、尿液和饮用水样本，并完成关于他们的水的调查问卷 利用历史。我们计划分析血液、尿液和饮用水中的GenX和相关化学物质； 血液和尿液样本也将用于临床测试(血脂、甲状腺功能、 肝功能和尿检)。研究的所有结果将与两个社区共享 作为一个整体和每一个参与者。我们将为这项研究设立一个社区咨询小组。 帮助就研究方案、向参与者报告结果的方法提供建议，以及 就当前或新出现的社区对GenX的担忧提供指导。该项目利用 北卡罗来纳州人类健康和环境中心应对新出现的 社会关注。

GenX (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate) is a short-chain perfluoroalkyl substance (PFAS) generated in the production of non-stick coatings. This chemical has been detected in the Cape Fear River in North Carolina. The Cape Fear River serves as a drinking water source for ~300,000 residents in the lower Cape Fear River basin, including residents of New Hanover, Brunswick, and Pender Counties. In June 2017, community concern about this chemical in drinking water resulted in multiple public meetings of citizens trying to obtain information about their potential exposure and resulting health effects associated with consumption of drinking water. As a result of community concern, the chemical plant has reportedly stopped discharging GenX into the river. However, it is still measurable in finished drinking water and community concern still exists. This project is designed to help address community questions about GenX exposure and health effects. Little is known about how GenX is stored in the body, the toxicity of GenX, or how long the chemical will remain in the environment. To address these questions, we plan to conduct a community-based study of lower Cape Fear River area residents who are served by public utility water. We will work with community partners of the Cape Fear River Watch and the New Hanover County Department of Health to help identify a representative sample of residents, to collect biological samples, and to keep the community informed about what is known about GenX and what the study finds. We plan to recruit ~400 Wilmington area residents (100 men, 100 women, 100 boys, 100 girls) to provide blood, urine, and drinking water samples and to complete a questionnaire on their water use history. We plan to analyze blood, urine, and drinking water for GenX and related chemicals; blood and urine samples will also be used for clinical tests (lipid profile, thyroid function, liver function, and urinalysis). All results from the study will be shared with both the community as a whole and each individual participant. We will have a community advisory panel for the study to help advise about study protocols, methods of reporting back results to participants, and provide guidance on ongoing or new community concerns about GenX. This project leverages the expertise of NC State’s Center for Human Health and the Environment to respond to an emerging community concern.