CSHL 2020 Glia in Health and Disease Conference

2020年冷泉港实验室会议 神经胶质细胞与健康和疾病 摘要 健康与疾病中的GLIA拟议会议将在冷泉港举行 实验室将于2020年7月16日至20日举行。这次会议的目标是提供一个积极的论坛 在快速发展的神经胶质生物学和神经元-神经胶质细胞相互作用领域的成果交流。 神经胶质细胞包括一组对神经系统至关重要的非神经细胞。 发育、回路功能和神经疾病。这些细胞执行许多重要的 作用，如控制细胞外离子和神经递质水平，为神经元提供 能源，包裹轴突以实现动作电位的快速传递 新陈代谢成本最低，并吞噬残骸。先进基因工具的发展 正在开始定义分子事件，这些事件建立和维持这些至关重要的 相互作用，为治疗操作提供新的靶点。此外，最近的研究 证明神经胶质细胞在调节神经功能方面发挥着更为积极的作用 神经回路；神经胶质细胞释放信号，调节神经放电、突触可塑性和行为， 并表达神经递质的受体。神经胶质细胞也通过以下方式对中枢神经系统损伤和疾病做出反应 形成胶质疤痕，吞噬濒临死亡的神经元和突触，并再生丢失的细胞。 然而，这些反应性变化可能会损害神经胶质细胞充分支持的能力。 神经元，或在某些情况下促进进一步的破坏。控制这些的机制 他们在疾病和伤害中的改变和行为改变的后果才刚刚开始 待定。现已清楚，许多基因突变与神经退行性变有关 老年痴呆症和肌萎缩侧索硬化症(ALS)等疾病也是 在神经胶质细胞中表达，基因操作研究开始揭示这些突变是如何 改变神经胶质细胞的功能，从而导致疾病。这次会议将突出最新的 通过研究无脊椎动物和脊椎动物模型系统而取得的进展 作为人脑器官，并提供了接触遗传学技术进步的机会， 分子生物学、生物化学、生理学和高分辨率成像。使用目标和 之前七次极为成功的会议的格式作为指导，我们计划：1)汇编一个 从事神经胶质生物学和神经胶质细胞研究的科学家国际会议 互动；2)通过选择演讲来讨论该领域令人兴奋的新发展 在科学价值的基础上公开提交摘要；3)为初级学生提供机会 来自不同背景的科学家展示他们的数据并参与科学话语 更有经验的调查人员；以及4)促进协作互动，以加快步伐 发现并确定治疗神经系统疾病的新方法。

2020 Cold Spring Harbor Laboratory Conference GLIA IN HEALTH & DISEASE Abstract The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory from July 16 – 20, 2020. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many important roles, such as controlling extracellular ion and neurotransmitter levels, providing neurons with energy sources, ensheathing axons to enable rapid transmission of action potentials with minimal metabolic cost, and phagocytosing debris. The development of advanced genetic tools is beginning to define the molecular events that establish and maintain these crucial interactions, providing new targets for therapeutic manipulation. In addition, recent studies demonstrate that glial cells play a much more active role in modulating the function of neural circuits; glial cells release signals that regulate neural firing, synaptic plasticity, and behavior, and express receptors for neurotransmitters. Glia also respond to CNS injury and disease by forming glial scars, engulfing dying neurons and synapses, and regenerating lost cells. However, these reactive changes can compromise the ability of glia to adequately support neurons, or in some cases promote further destruction. The mechanisms that control these changes and the consequences of their altered behavior in disease and injury are just beginning to be defined. It has become clear that many gene mutations linked to neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS), are also expressed in glia, and genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. This meeting will highlight the latest developments obtained through studies of invertebrate and vertebrate model systems, as well as human brain organoids, and provide exposure to technological advances in genetics, molecular biology, biochemistry, physiology, and high-resolution imaging. Using the goals and format of the seven prior extremely successful meetings as a guide, we plan to: 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to treat diseases of the nervous system.