Molecular and Structural Biology (MSB)

15.0翻译后摘要：分子和结构生物学计划 UMCCC的分子和结构生物学（MSB）计划的总体目标是阐明 在癌症中改变的分子机制和细胞过程，并鼓励这些 基本的科学发现，以发展新的战略，治疗癌症。为了实现这些目标， 该计划重点关注三个主题：主题1：DNA修复和检查点信号表征 DNA修复和检查点信号传导的缺陷，并了解这些缺陷如何影响癌症 主题2：不适当的基因表达-决定转录和 转录后过程导致癌症中蛋白质表达的不适当调节;以及主题3： 癌基因和肿瘤抑制因子-描绘信号通路（即，致癌的，肿瘤 抑制器等）在癌症中被解除管制，并确定可以靶向 扭转这些影响。 MSB计划有50名成员，代表16个学术部门和6所学校的大学 马里兰州。该项目的成员进行以癌症为重点的研究，每年获得678万美元的资金。 资金，包括来自NCI的234万美元和来自其他同行评审来源的358万美元。此外该 MSB计划成员每年从非同行审查的资金来源获得超过86万美元。之间 2010年1月和2014年12月，MSB成员撰写了664篇癌症相关出版物，其中13篇 18%来自方案内合作，18%来自方案间合作。约 48%的出版物代表与外部研究人员的合作。MSB的研究工作 教师通过广泛使用SBSS，FCSS，TLSS，PBSS，ISS和BSS来支持。

15.0 Abstract: Molecular and Structural Biology Program The overarching goals of the Molecular and Structural Biology (MSB) Program of UMGCC are to elucidate molecular mechanisms and cellular processes that are altered in cancer and to encourage translation of these basic scientific findings toward the development of novel strategies for treating cancer. To achieve these goals, the program focuses on three themes: Theme 1: DNA repair and checkpoint signaling—characterizing defects in DNA repair and checkpoint signaling and understanding how these defects impact cancer development; Theme 2: Inappropriate gene expression—determining how defects in transcriptional and posttranscriptional processes lead to inappropriate regulation of protein expression in cancer; and Theme 3: Oncogenes and tumor suppressors—delineating how signaling pathways (i.e., oncogenic, tumor suppressor, etc.) are deregulated in cancer and identifying specific biomolecules that can be targeted to reverse these effects. The MSB Program has 50 members representing 16 academic departments and 6 schools of the University of Maryland. Members of the program conduct cancer-focused research that receives $6.78 million total annual funding, including $2.34 million from NCI and $3.58 million from other peer-reviewed sources. In addition, the MSB Program members receive over $0.86 million annually from non-peer-reviewed funding sources. Between January 2010 and December 2014, MSB members authored 664 cancer-related publications, of which 13 percent resulted from intraprogrammatic and 18 percent from interprogrammatic collaborations. Approximately 48 percent of the publications represent collaborations with external investigators. Research efforts by MSB faculty are supported by extensive use of the SBSS, FCSS, TLSS, PBSS, ISS, and BSS.