West African Center of Excellence for Global Health Bioinformatics Research Training

项目摘要/摘要 人类基因组计划的完成和生物信息学技术的进步提供了巨大的 更好地了解非洲人口中广泛的遗传和微生物区系多样性的机会 对感染和代谢性疾病的易感性和抵抗力有更深的了解。在过去的十年里， 巴马科大学-USTTB参与了非洲的生物信息学/基因组学能力建设 来自世界卫生组织、H3非洲和美国国立传染病研究所的支持 过敏(NIAID)。NIAID的承诺最近随着第一个NIAID-USTTB的创建而扩大 非洲生物信息学卓越中心(ACEB)和一个区域临床研究中心(UCRC) 美国科技大学巴马科大学。拟议的计划将支持这些努力，总体目标是建立一个 可持续的生物信息学研究培训计划，将促进基因组学方法，以解决全球 非洲的健康问题。拟议方案将通过以下目标实现这一目标：1] 加强地方对生物信息学培训和研究的领导，以满足对先进技术的需求 生物信息学和数据科学在非洲的研究专长。2]增强现有毕业生生物信息学 在巴马科大学接受培训，包括博士课程和生物信息学高级课程 和基因组学；3]培养和促进受训人员的职业生涯，并为临床和实验室提供支持 研究人员利用生物信息学和基因组学方法解决全球健康问题。的活动 这笔培训赠款将包括不同领域的教师和导师发展(生物信息学、生物统计学、 计算生物学、基因组学和蛋白质组学)，供教师、临床和实验室研究人员使用 USTTB.参与的学院还将与杜兰大学的合作者合作，提高他们的 生物信息学课程和课程内容。这项拟议的计划将支持3名理科硕士新生 每年生物信息学(马里和其他非洲国家)，允许15名非洲学生完成硕士学位 在5年的授权期内获得学位。这笔助学金还将支持在华中科技大学注册的5名博士生，为期3年- 四年生物信息学博士学位课程。培训计划涉及已建立的合作伙伴 巴马科大学-USTTB、杜兰大学、斯特拉斯堡大学和国立卫生研究院将满足对 H3非洲联盟的生物信息学研究专长并导致生物信息学中心的可持续发展 为非洲大陆提供与全球卫生研究相关的研究培训。

Project Summary/Abstract The completion of the Human Genome Project and the advances in Bioinformatics technology provide great opportunity for better understanding the extensive genetic and microbiota diversity in African populations and a deeper understanding of susceptibility and resistance to infections and metabolic diseases. In the past decade, University of Bamako-USTTB has been involved in bioinformatics/genomics capacity building in Africa with support from World Health Organization, H3Africa, and the National Institutes of Infectious Diseases and Allergy (NIAID). NIAID's commitment was recently expended with the creation of the first NIAID-USTTB' African Center of Excellence in Bioinformatics (ACEB) and a Regional Clinical Research Center (UCRC) at University of Bamako-USTTB. The proposed program will support those efforts with overall goal to build a sustainable bioinformatics research training program that will foster genomics approaches to address global health issues in Africa. The proposed program will achieve the following this goal through the following aims: 1] Strengthen local leadership in bioinformatics training and research to address the need for advanced bioinformatics and data sciences research expertise in Africa. 2] Enhance existing graduate bioinformatics training at University of Bamako-USTTB including a doctoral program and advances courses in Bioinformatics and genomics; 3] Produce and enhance the careers of trainees and provide support to clinical and laboratory researchers for use of bioinformatics and genomics approaches to address global health issues. Activities of this training grant will include faculty and mentorship development in various fields (bioinformatics, biostatistics, computational biology, genomics, and proteomics) for teaching faculty, clinical and laboratory researchers of USTTB. Participating faculties will also work with collaborators of Tulane University to improve their bioinformatics curricula and course contents. This proposed program will support for 3 new MSc students in Bioinformatics annually (Malian and other African countries), allowing 15 African students to complete a Master degree over the 5-year grant period. The grant will also support 5 PhD students enrolled at USTTB for a three- four year doctorate program in Bioinformatics. The training program involving established collaborators of University of Bamako-USTTB, Tulane University, University of Strasbourg and NIH will address the need for bioinformatics research expertise in the H3Africa Consortium and result in sustainable center of bioinformatics research training relevant to global health research for the African continent.