Ohio Valley Node-Network (OVNN) of the NIDA Clinical Trials Network

项目摘要-摘要： 自2000年成立以来，俄亥俄山谷节点(OVN)一直是NIDA中生产率最高的节点之一 临床试验网络(CTN)节点，领导和参与多站点试验。在此应用程序中， OVN已经扩展为一个网络节点：俄亥俄山谷节点网络(OVNN)。OVNN包括 位于6个州的8个原始OVN站点，每年治疗超过22.5万名患者；以及3个 其他基于实践的研究网络(PBRN)。其中两个是全州范围的初级保健PBRN， 俄亥俄州合作研究网络(COIN)和威斯康星州研究和教育网络(WREN)， 加在一起，包括350多个诊所，每年治疗400多万名患者。第三个是 印第安纳州的一家全州药房PBRN，其中包括168家药店，满足150万张处方 每年一次。这些中西部地区和合作伙伴关系将为CTN临床试验带来所需的多样性。这个 OVNN研究核心是OVNN的驱动力，由最顶尖的专家之一温胡森博士领导 在临床实践环境中进行多部位成瘾临床试验。OVNN联合调查员包括 初级保健(老年人)、急救医学(里昂)和儿科急救医学(Grupp- Phelan)实践为基础的研究。OVN研究-实施团队的7名成员带来了72年的 具有进行CTN临床试验的经验。该应用程序的一个主要目标是进行 为有效预防物质使用障碍(SUD)提供临床实践指南所需的研究 和一般医疗保健环境中的治疗，这在很大程度上是缺乏的，但日益需要， 具体侧重于解决阿片类药物滥用流行的研究。我们建议的研究议程包括 务实的临床试验，测试干预措施，以预测、预防和应对初级保健中的阿片类药物滥用； 通过将因阿片类药物过量而接受急诊治疗的患者联系起来，减少阿片类药物过量的再次发生 医疗部门通过一种新的以同伴为基础的干预措施进行SUD治疗；并减少 丁丙诺啡治疗患者通过药房检测传播艾滋病毒和丙型肝炎病毒。

Project Summary-Abstract: Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. In this application the OVN has been expanded to be a node of networks: the Ohio Valley Node-Network (OVNN). The OVNN includes eight original OVN sites, which are located in 6 states and treat more than 225,000 patients per year; and three additional practice based research networks (PBRNs). Two are state-wide primary care PBRNs, the Collaborative Ohio Inquiry Network (COIN) and the Wisconsin Research and Education Network (WREN), which, combined, include more than 350 practices and treat more than 4 million patients per year. The third is a state-wide pharmacy PBRN in Indiana, which includes 168 pharmacies that fill 1.5 million prescriptions annually. These Midwestern sites and partnerships will contribute needed diversity to CTN clinical trials. The OVNN Research Core is the driving force of the OVNN and is led by Dr. Winhusen, one of the foremost experts in conducting multi-site addiction clinical trials in clinical practice settings. The OVNN co-investigators include experts in primary care (Elder), emergency medicine (Lyons), and pediatric emergency medicine (Grupp- Phelan) practice-based research. The 7 members of the OVN research-implementation team bring 72 years of combined experience conducting CTN clinical trials. A primary goal of the application is to conduct the research needed to inform clinical practice guidelines for effective substance use disorder (SUD) prevention and treatment in general medical care settings, which are largely lacking but increasingly needed, with a specific focus on research to address the opioid abuse epidemic. Our proposed research agenda includes pragmatic clinical trials testing interventions to predict, prevent, and respond to opioid misuse in primary care; to reduce the reoccurrence of opioid overdose by linking patients treated for an overdose in emergency medicine departments to SUD treatment through a novel peer-based intervention; and to reduce the transmission of HIV and HCV through pharmacy-based testing for buprenorphine-treated patients.