Mapping the dynamics of corneal stem cell during aging and after wounding and transplantation

恢复角膜失明患者的视力是我们的重点。在实现这一目标之前，我们需要了解角膜干细胞的功能。由于许多原因，这些研究不能在人类身上进行，所以我们设计了一种小鼠，可以无限期地跟踪这些细胞的定位、迁移、分裂、分化和死亡。这些信息将使我们能够改进目前的治疗方案，并为失明角膜疾病患者开发新的临床解决方案。

Restoring vision in patients with corneal blindness is our focus. Before this can be achieved we need to understand how corneal stem cells function. For many reasons these studies cannot be performed in man, so we engineered a mouse in which the location, migration, division, differentiation, death of these cells can be followed indefinitely. This information will allow us to improve current therapeutic options and develop new clinical solution for patients with blinding corneal disease.