Center for Urban Responses to Environmental Stressors (CURES)

位于底特律中心的城市响应中心的环境健康科学“身份” 环境应激源(治疗)是为了了解环境暴露对健康的影响 底特律城市景观中复杂的化学和非化学污染物。我们的战略愿景是 与以下公司密切合作，发挥领导作用，识别、评估和缓解环境健康问题 社区和环境政策制定者。Cres组建了一支独特的跨学科团队 已建立和新成立的环境健康科学家和社区合作伙伴，以解决主要环境问题 底特律种族和民族多元化人口面临的健康挑战。我们假设“现代” 影响居民生活质量的疾病(如心血管疾病、癌症、糖尿病) 在工业化的城市环境中，如底特律，是动态相互作用的结果 在个体的遗传和表观遗传构成、营养状况和环境应激源中， 重新编程关键的细胞网络以支持发病机制。Caures推进NIEHS 2012-2017战略 通过与底特律城市社区建立牢固的联系来制定计划，应用翻译和跨学科 团队研究方法，以解决复杂的环境健康问题，并通过寻找 环境健康差距。治疗方案正在我们地区产生影响。我们的研究人员和社区 合作伙伴迅速和协调地对我们邻近地区正在出现的严重健康危机作出反应； 2015-2016密歇根州弗林特主要流域污染灾难。为了打造一个健康底特律的门户， CURES的短期目标是：1)加强现有的伙伴关系，并继续发展新的伙伴关系 在Caures和底特律社区之间；2)与他们合作，确定主要的环境 对底特律脆弱人群的健康威胁；3)进行高度综合的机械性、流行病学、 和社区参与的研究，解决城市环境暴露对人类的影响 健康；4)通过提供下列设施核心，建设治疗能力，以实现其研究目标 优化以满足其成员和种子资金的需求，以支持试点项目探索可行性 新的研究领域；以及5)通过以下方式加强治疗对环境健康科学领域的影响 为新的和现有的调查人员提供指导，支持他们的专业目标和准备 他们在环境健康研究中发挥领导作用。我们的长期目标是：1)提高我们的 社区合作伙伴努力提高社区意识并促进更健康的计划 社区和2)根据治疗研究制定适当的战略，以便为政策提供信息，以便 减轻与城市环境暴露相关的风险。我们相信治愈是最好的 定位于最有希望实现以下目标的创新团队科学机会的“底层” 实现我们有生之年对城市环境疾病的早发现、早预防、早根除。

Situated in the heart of Detroit, the environmental health sciences “identity” of the Center for Urban Responses to Environmental Stressors (CURES) is to understand the health impacts of environmental exposures to complex chemical and non-chemical contaminants in Detroit's urban landscape. Our strategic vision is to provide leadership to identify, evaluate, and mitigate environmental health concerns in close collaboration with the community and environmental policy makers. CURES has assembled a unique interdisciplinary team of established and new environmental health scientists and community partners to address major environmental health challenges facing Detroit's racially and ethnically diverse population. We hypothesize that “modern-era” diseases (e.g., cardiovascular disease, cancer, diabetes) that compromise the quality of life of residents living in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which re-program key cellular networks to favor pathogenesis. CURES advances the NIEHS 2012-2017 Strategic Plan by nurturing strong bonds with Detroit's urban community, applying translational and interdisciplinary team-research approaches to solve complex environmental health problems, and by seeking the sources of environmental health disparities. CURES is making an impact in our region. Our researchers and community partners responded rapidly and coordinately to a serious emerging health crisis in our immediate vicinity; the 2015-2016 lead watershed contamination disaster in Flint, Michigan. To create a gateway to a healthy Detroit, CURES' short-term goals are to: 1) strengthen existing partnerships and continue to develop new ones between CURES and the Detroit community; 2) in collaboration with them, identify the chief environmental health threats to Detroit's vulnerable populations; 3) conduct highly integrated mechanistic, epidemiological, and community-engaged research that addresses the impact of urban environmental exposures on human health; 4) build the capacity of CURES to accomplish its research goals by providing facility cores that are optimized to meet the needs of its members and seed funds to support pilot projects to explore the feasibility of new areas of study; and 5) enhance the impact of CURES on the field of environmental health science by providing mentoring to new and established investigators that supports their professional goals and prepares them for leadership roles in environmental health research. Our long-term goals are to 1) enhance our community partners' efforts to increase community awareness and facilitate programs for a healthier community and 2) develop appropriate strategies, based on CURES research, to inform policy so as to mitigate the risks associated with urban environmental exposures. We believe that CURES is optimally positioned on "the ground floor" of innovative team science opportunities that have the greatest promise to realize the early detection, prevention, and eventual eradication of urban environmental disease in our lifetime.