Exposure Assessment, Biomarkers, and Environmental Sensing Facility Core

摘要 暴露评估、生物标志物和环境传感（EABES）设施核心（以前称为 暴露评估、生物标志物和代谢组学核心）为EDGE研究者提供了 最先进的分析方法、仪器和曝光科学专业知识， 通过纳入高质量的转化和基于人口的环境健康科学研究 暴露评估。EABES设施核心的使命是为EDGE调查人员提供 了解采样问题的知识和专业知识，支持暴露的设计和实施 评估，执行环境或生物样本的实验室分析，并协助数据 解释。在该中心的下一个供资周期，EABES设施核心将继续扩大访问 到最先进的仪器-特别是扩展使用激光消融的组织成像的专业知识- 电感耦合等离子体质谱（LA-ICPMS），用于测量暴露和暴露特征 在生物样本中。核心还将扩大获得最先进的仪器，包括GPS- 启用的个人暴露监测器，用于测量生物样品中的暴露和暴露特征。 在这个核心中开发的新仪器将通过以下方式提高我们对个人暴露的理解： 允许在实地研究中进行更大的样本，以调查环境污染物的邻近浓度， 危害和个人接触模式。

ABSTRACT The Exposure Assessment, Biomarkers and Environmental Sensing (EABES) Facility Core (formerly known as the Exposure Assessment, Biomarkers and Metabolomics Core) provides EDGE investigators with access to state-of-the-art analytical methods, instrumentation and exposure science expertise, to stimulate their translational and population-based environmental health science research through inclusion of high quality exposure assessment. The mission of the EABES Facility Core is to provide EDGE investigators with the knowledge and expertise to understand sampling issues, support the design and implementation of exposure assessments, perform the laboratory-based analysis of environmental or biological samples and aid in the data interpretation. In the next funding cycle of the Center, the EABES Facility Core will continue to expand access to state-of-the-art instrumentation – in particular expanding expertise in tissue imaging using laser ablation- inductively coupled plasma mass spectrometry (LA-ICPMS), for measuring exposure and exposure signatures in biological samples. The Core will also expand access to state-of-the-art instrumentation by including GPS- enabled personal exposure monitors, for measuring exposure and exposure signatures in biological samples. The new instrumentation developed in this core will improve our understanding of personal exposure by allowing for larger samples in field studies to investigate both neighborhood concentrations of environmental hazards and personal-level patterns of exposure.