Cancer Center Support (CORE) Grant

总体项目总结 杰克逊实验室癌症中心(JAXCC)的任务是发现精确的基因组解决方案 通过做出对人类有影响的基本发现来治疗癌症。致力于我们作为基础研究癌症的角色 中心，我们利用我们在复杂遗传学和功能基因组学方面的跨学科优势来实现这一目标 进球。组织了一个单一的研究计划，精准癌症遗传模型医学，53名正式成员 将JAXCC在小鼠体内模拟人类癌症的独特能力与基因组和 人类癌症的计算分析来解决这个广泛的问题。从RNA生物学到染色质 动力学，从生物体到癌症的硅胶模型，从基因多样性菌株的面板到人性化 小鼠，从单细胞基因组学到患者来源的异种移植，从基因组工程技术到 基因组诊断-JAXCC通过以下方式带来先进技术来应对持续存在的癌症问题 与临床研究人员建立协作伙伴关系。自2013年以来，我们实现了前所未有的增长，达到22 拥有免疫学、计算生物学、基因组技术、表观遗传学、 微生物组、肿瘤微环境和临床基因组学。共享资源(癌症模型 开发资源、计算科学、基因工程技术、基因组和单细胞 技术和表型技术)为这一广泛的研究提供了全面的支持。 协作环境、强大技术的使用以及我们对发展资金的使用 取得重大进展：在过去5年中，我们从NCI和其他机构获得的资金增加了一倍多 并将我们的总体方案内赠款协作率从21%提高到47%。我们的 翻译影响包括利用基因组不稳定性的治疗方法的发展；我们作为一个发现的角色 SWOG的引擎和我们新的社区癌症基因组教育倡议，缅因州癌症基因组学 主动权。在接下来的五年里，JAXCC将利用我们扩大的癌症中心的集体能量。 我们将确定癌症中复杂结构基因组变化的起源和后果；我们将 基因复杂的癌症模型，以揭示疾病的系统生物学；我们将探索细胞 原代癌细胞在培养中的动态变化，以揭示治疗不敏感的遗传原因；我们将 通过体内和体外组织重建探索肿瘤与微环境的相互作用。我们的目标是 下一个赠款周期是将几种诊断和治疗方法应用于临床开发。此外，我们还将 建立癌症教育和职业促进核心，支持学生的连续学习， 实习生、早期职业调查人员和缅因州社区肿瘤护理提供者。我们对复杂环境的关注 遗传学和功能基因组学，我们的模型创建和实验的规模，以及 我们多样化的人才使JAXCC成为一家独特的企业。

PROJECT SUMMARY OVERALL The mission of The Jackson Laboratory Cancer Center (JAXCC) is to discover precise genomic solutions for cancer by making basic discoveries with human impact. Committed to our role as a basic research Cancer Center, we harness our transdisciplinary strengths in complex genetics and functional genomics to achieve this goal. Organized in a single research program, Genetic models for precision cancer medicine, the 53 full members combine the JAXCC's unique capabilities to model human cancers in mice with innovations in genomic and computational analytics of human cancers to attack this broad problem. From RNA biology to chromatin dynamics, from organismal to in silico models of cancer, from panels of genetically diverse strains to humanized mice, from single cell genomics to Patient Derived Xenografts, from genomic engineering technologies to genomic diagnostics—The JAXCC brings advanced technologies to bear on persistent cancer problems through collaborative partnerships with clinical investigators. Since 2013, we achieved unprecedented growth with 22 new members with expertise in immunology, computational biology, genomic technologies, epigenetics, microbiome, tumor microenvironment, and clinical genomics. The Shared Resources (Cancer Model Development Resource, Computational Sciences, Genetic Engineering Technologies, Genome and Single Cell Technologies, and Phenotyping Technologies) provide comprehensive support for this wide range of research. The collaborative environment, access to powerful technologies, and our use of Developmental Funds has yielded significant advances: in the past 5 years, we have more than doubled our funding from NCI and other cancer agencies and increased our overall intra-programmatic grant collaborative rate from 21% to 47%. Our translational impact includes development of therapeutics exploiting genomic instability; our role as a discovery engine for SWOG and our new community cancer genomic education initiative, the Maine Cancer Genomics Initiative. In the next five years, the JAXCC will harness the collective energy of our expanded Cancer Center. We will identify origins and the consequences of complex structural genomic alterations in cancer; we will craft genetically complex models of cancer to uncover the systems biology of the disease; we will explore the cellular dynamics of primary cancer cells in culture to uncover genetic causes of therapeutic insensitivity; and we will explore tumor-microenvironment interactions through in vivo and in vitro tissue reconstructions. Our goal in the next grant cycle is to bring several diagnostics and therapeutics to clinical development. In addition, we will establish a Cancer Education and Career Enhancement core that supports a continuum of learning for students, trainees, early career investigators and the Maine community oncology care providers. Our focus on complex genetics and functional genomics, the scale of our model creation and experimentation, and the integration of our diverse talents make the JAXCC a unique enterprise.