Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.

项目摘要 放射性药物治疗(RPT)-使用靶向放射性核素将辐射专门传递到 癌细胞及其微环境--是一种从根本上不同的癌症治疗方法，这种方法正在增长， 有大量的大小制药公司在这一领域开发产品， 放射性核素生产商在扩大生产方面进行了大量投资。这一点在 阿尔法发射器的面积。治疗性放射性药物的剂量学评估是 RPTS的监管批准和最佳管理，特别是与外照射相结合 心理治疗。该项目将提供基于云的剂量测量软件服务，通过网络浏览器提供， 这包括在获得监管批准的情况下剂量测定所需的全部方法 并最终实现最佳的临床给药。在基于云的系统中提供此功能将实现多种 销售服务的模式不需要为诊所或 放射性药物开发商。它还将提供对专家的建议、定制和剂量测定 服务，并允许开发人员、剂量学专家和临床站点之间的协作。要完成 为了开发这种基于云的Web浏览器交付的RPT剂量测量软件服务，我们提出了 具体目标如下：(1)设计、开发和实施基于Web/云的集成软件系统 RPT治疗计划；(2)设计并实现完整的订阅服务器端框架， 认证，并为剂量测定管道中的各种过程和数据授予协作特权； (3)优化和调整四个计算密集度最高的进程，以实现基于云的多处理器 计算环境；(4)将AIMS 1-3中开发的工具链应用于模型、模拟和评估 现有的患者数据。该项目的成功完成将产生一个基于云的软件系统交付 通过为RPT提供集成的、简化的、强大的、最先进的系统的Web浏览器 治疗计划。该系统将实现多中心临床试验的协作方法 最终达到临床最佳剂量的RPT。

Project Summary Radiopharmaceutical therapy (RPT) – the use of targeted radionuclides to deliver radiation specifically to cancer cells and their microenvironment – is a fundamentally different approach to cancer therapy that is growing, with a substantial number of large and small pharmaceuticals companies developing products in this area and radionuclide producers making substantial investments in scaling up production. This is especially true in the area of alpha emitters. The dosimetric evaluation of therapeutic radiopharmaceuticals is a key requirement for regulatory approval and optimal administration of RPTs, especially in combination with external beam radiation therapy. This project will provide a cloud-based dosimetry software service, delivered through a web-browser, that includes the full complement of methods needed for dosimetry in the context of obtaining regulatory approval of RPTs and, ultimately, for optimal clinical delivery. Providing this in a cloud-based system will enable a variety of models for selling the service that do not require a large up-front capital investment for clinics or radiopharmaceutical developers. It also will provide access to expert advice, customization, and dosimetry services, and allow for collaboration between developers, dosimetry experts, and clinical sites. To accomplish the goal of developing this cloud-based web-browser-delivered RPT dosimetry software service, we propose the following specific aims: (1) Design, develop and implement a web/cloud-based integrated software system for treatment planning of RPT therapy; (2) design and implement a full server-side framework for subscription, authentication, and granting collaborative privileges for the various processes and data in the dosimetry pipeline; (3) optimize and adapt the four most computationally intensive processes for a multi-processor cloud-based compute environment; (4) apply and evaluate the toolchain developed in aims 1-3 to phantom, simulated and existing patient data. Successful completion of this project will produce a cloud-based software system delivered to the user via a web browser that provides an integrated, streamlined, robust, state-of-the-art system for RPT treatment planning. This system would enable a collaborative approach to multi-center clinical trials and eventually to clinical delivery of optimally dosed RPT.